TITLE:
Broad Antibacterial Activity of Bothrops jararaca Venom against Bacterial Clinical Isolates
AUTHORS:
Lucas Henrique Cendron, Charise Dallazen Bertol, Daiane Bopp Fuentefria, Elza Maria Calegari, Eliane Dallegrave, Dinara Jaqueline Moura, Kátia Moura, Maria da Graça Marques, Luciana Grazziotin Rossato
KEYWORDS:
Snake Venom, Antibiotic Potential, Toxinology, Bothrops
JOURNAL NAME:
Advances in Microbiology,
Vol.4 No.16,
December
3,
2014
ABSTRACT: Purpose: To evaluate the antibacterial
activity of Bothrops jararaca venom against bacterial clinical isolates.
Methods: Antibacterial activity of Bothrops jararaca venom was evaluated
through agar diffusion method against the following bacteria: Acinetobacter
baumannii, Oxacillinase-producing Acinetobacter baummanii, extended-spectrum
β-lactamase-producing (ESBL) Enterobacter aerogenes, Escherichia coli,
Escherichia coli ESBL, Klebsiella pneumoniae, Klebsiella pneumoniae ESBL, Proteus mirabilis, Pseudomonas aeruginosa, metallo β-lactamase-producing Pseudomonas aeruginosa, Staphylococcus aureus, oxacillin resistant Staphylococus aureus (ORSA), Staphylococcus epidermidis, and oxacillin resistant Staphylococus epidermidis.Minimum inhibitory concentration was
determined through microdilution plate protocol. Results: The venom presented
antibacterial activity against all tested bacteria. More pronounced results
were observed to Gram- positive bacteria, especially against ORSA. Conclusion:
The present study evidenced the great antibacterial potential of Bothrops
jararaca venom showing promising results even with resistant bacterial clinical
isolates.