TITLE:
The relationship among periodontal condition, serum lipid, and electrocardiographic abnormalities in the elderly: A prospective cohort study
AUTHORS:
Lisdrianto Hanindriyo, Akihiro Yoshihara, Toshinobu Hirotomi, Hideo Miyazaki
KEYWORDS:
Periodontal Condition; Serum Lipid; Cardiovascular Disease; Elderly People
JOURNAL NAME:
Open Journal of Stomatology,
Vol.3 No.8,
November
28,
2013
ABSTRACT:
Periodontal disease is recognized as a risk factor for
cardiovascular disease (CVD). Some studies have
suggested that serum lipids might play a role in the association between periodontal disease and CVD. However, this hypothesis remains unproven. Present
study evaluated the association between periodontal disease and CVD-related
parameters including electrocardiographic (ECG) parameters and serum lipid
levels in the elderly. This study was a prospective cohort study. A total of 107 subjects (57 males and 50 females) from Niigata City’s community-dwelling
elderly (all aged 75 years old) who possessed at least 20 teeth and did not
exhibit ECG abnormalities at the baseline underwent annual examinations for 5
years. Logistic
regression analysis was used to assess the relationship between periodontal
condition and the presence of ECG abnormalities, after adjusting for
confounding factors including serum lipid levels. Logistic regression analysis showed that the
subjects who exhibited a poor periodontal condition at the baseline had a 2.97
times greater risk of suffering from ECG abnormalities than the subjects who displayed a good periodontal condition at the baseline (p = 0.019). Furthermore, the subjects who displayed a poor
periodontal condition and an unfavorable serum lipid profile at the baseline
showed a significantly higher frequency of
ECG abnormalities (63.6%) than those who exhibited a healthy periodontal
condition and a favorable serum lipid profile (21.6%, p = 0.008) as well as those who displayed a healthy periodontal
condition and an unfavorable serum lipid profile (21.4%, p = 0.010). As a conclusion, periodontal condition could be a marker of CVD, even in
the healthy elderly.