Prof. Yves Mély
Faculty of
Pharmacy
Louis Pasteur University, France
Professor
Email: yves.mely@unistra.fr
Qualifications
2011 Honorary Doctor, University of Kiev
1993-2009 Research and doctoral directory bonus
Publications
(Selected)
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V.J. GREINER, C. EGELE, S. ONCUL,
F. RONZON, C. MANIN, A. KLYMCHENKO, & Y. MELY. Characterization of the
lipid and protein organization in HBsAg viral particles by steady-state and
time resolved fluorescence spectroscopy. Biochimie, 2010, 92, 994-1002. IF=3.5.
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C. BOUDIER, R. STORCHAK, P. DIDIER,
A. FOLLENIUS-WUND, S. MULLER, J.-L. DARLIX and Y. MELY. Investigating the
annealing activity of the HIV-1 trans-activator of transcription TAT. J. Mol.
Biol., 2010, 400, 487-501. IF = 4.3.
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J.V. FRITZ, L. BRIANT, Y. MELY, S.
BOUAZIZ, & H. de ROCQUIGNY. HIV-1 Viral Protein R : from structure to
function. Future Virology. 2010, 5, 607-625. IF=0.7.
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K. AMARI, E. BOUTANT, C. HOFMANN,
C. SCHMITT-KEICHINGER, L. FERNANDEZ-CALVINO, P. DIDIER, A. LERICH, J. MUTTERER,
C. THOMAS, Y. MELY, A. MAULE, & C. RITZENTHALER. Plasmodesmal proteins with
receptor-like properties for plant viral movement proteins. Plos Pathogens.
2010., 6, e1001119 (10 pages) IF = 9.7. Cited in the Faculty of 1000 Biology.
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J. GODET, & Y. MELY. Biophysical studies of the nucleic
acid chaperone properties of the HIV-1 nucleocapsid protein. RNA Biology, 2010,
7, 48-60. IF=5.6.
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V. Y. POSTUPALENKO, V. V.
SHVADCHAK, G. DUPORTAIL, V. G. PIVOVARENKO, A. S. KLYMCHENKO, & Y. MELY.
Monitoring membrane binding and insertion of peptides by two-color fluorescent
label. Biochim Biophys Acta- Biomembranes, 2011, 1808, 424-32. IF = 4.4.
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N. JAIN, Y. ARNTZ, V. GOLDSCHMIDT,
G. DUPORTAIL, Y. MELY, & A.S. KLYMCHENKO. New unsymmetrical
bolaamphiphiles: synthesis, assembly with DNA and application for gene
delivery. Bioconjug Chem. 2010, 21, 2110-2118. IF=4.8.
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A. PERRINO, A. KLYMCHENKO, A.
MORERE, E CONTAL, A RAMEAU, J.M. GUENET, Y MELY, & A. WAGNER. Insight into
the structure and behaviour of polydiacetylene-based micelles. Macromol. Chem.
Phys., 2010, 212, 111-117. IF=2.6.
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Y. SATO, N. RAMALANJAONA, T. HUET,
N. POTIER, J. OSZ, P. ANTONY, C. PELUSO-ILTIS, P. POUSSIN-COURMONTAGNE, E.
ENNIFAR, Y. MELY, A. DEJAEGERE, D. MORAS, & N. ROCHEL. The “Phantom Effect”
of the Rexinoid LG100754: Structural and Functional Insights. PLoS ONE 2010, 5,
e15119.
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S. LECAT, M. OUEDRAOGO, T.
CHERRIER, F. NOULET, P. RONDE, N. GLASSER, J.L. GALZI, Y. MELY, K. TAKEDA,
& B. BUCHER. Contribution of a tyrosine-based motif to cellular trafficking
of wild type and truncated NPY Y1 receptors. Cell Signal. 2011, 23, 228-238.
IF=4.1.
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A. BAZZI, L. ZARGARIAN, F.
CHAMINADE, C. BOUDIER, H. de ROCQUIGNY, B. RENE, Y. MELY, P. FOSSE, & O.
MAUFFRET. Structural
insights into the cTAR DNA recognition by the HIV-1 Nucleocapsid protein: role
of sugar deoxyriboses in the binding polarity of NC. Nucleic Acids Res, 2011,
39, 3903-3916. IF=7.5.
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O. ZAMOTAIEV, V. POSTUPALENKO, V.
SHVADCHAK, V. PIVOVARENKO, A. KLYMCHENKO, & Y. MELY. Improved
hydration-sensitive dual-fluorescence labels for monitoring peptide-DNA
interactions. Bioconjug. Chem. 2011, 22, 101-107. IF=4.8.
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E. CONTAL, A. KLYMCHENKO, Y. MELY,
S. MEUNIER, & A. WAGNER. Core functionalization of polydiacetylene micelles by « click » reaction. Soft matter, 2011, 7,
1648-1650. IF=5.4
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N. ROCHEL, F. CIESIELSKI, J. GODET,
E. MOMAN, M. ROESSLE, C. PELUSO-ILTIS, Y. MELY, D. I. SVERGUN, & D. MORAS.
Solution structures of 3 nuclear receptors heterodimers RXR/RAR, RXR/VDR and
RXR/PPAR on DNA. Nat. Struct. Mol. Biol. 2011, 18, 564-570. IF=12.3.
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R. V. RODIK, A.S. KLYMCHENKO, N.
JAIN, S.I. MIROSHNICHENKO, L. RICHERT, V.I. KALCHENKO, & Y. MELY.
Virus-sized DNA nanoparticles for gene delivery based on micelles of cationic
calixarenes. Chemistry- A European Journal. 2011, 17, 5526-5538. IF =5.56.
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B. GRIGOROV, A. BOCQUIN, C. GABUS,
S. AVILOV, Y. MELY, A. AGOPIAN, G. DIVITA, M. GOTTIKH, M. WITVROUW, & J.L.
DARLIX. Identification of a methylated oligoribonucleotide as a potent
inhibitor of HIV-1 reverse transcription. Nucleic Acids Res., 2011, 39,
5586-96. IF=7.5.
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J.L. DARLIX, J. GODET, R.
IVANYI-NAGY, P. FOSSE, O. MAUFFRET, & Y. MELY. Flexible nature and specific
functions of the HIV-1 Nucleocapsid protein. J. Mol. Biol. 2011, 410, 565-81.
IF=4.3
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J. GODET, N. RAMALANJAONA, K.K.
SHARMA, L. RICHERT, H. de ROCQUIGNY, J.L. DARLIX, G. DUPORTAIL, & Y. MELY.
Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing
of the Primer Binding Site complementary sequences during the obligatory plus
strand transfer. Nucleic Acids Res., 2011, 39, 6633-6645. IF=7.5.
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V. GREINER, V. SHVADCHAK, Y. ARNTZ,
J FRITZ, P. DIDIER, B. FRISCH, C. BOUDIER, Y. MELY, & H. DE ROCQUIGNY.
Characterization of the mechanisms of Vpr(52-96) internalization in cells.
Biochimie, 2011, 93, 1647-58. IF=3.2. Adrerus thesis
prize in 1990.