Article citationsMore>>
Harris, N.L., Jaffe, E.S., Stein, H., Banks, P.M., Chan, J.K., Cleary, M.L., Delsol, G., De Wolf-Peeters, C., Falini, B., Gatter, K.C., et al. (1994) A Revised European-American Classification of Lymphoid Neoplasms: A Proposal from the International Lymphoma Study Group. Blood, 84, 1361-1392.
https://www.ncbi.nlm.nih.gov/pubmed/8068936
has been cited by the following article:
-
TITLE:
Epstein Bar Virus—The Cause of Hodgkin’s Lymphoma
AUTHORS:
Ilija Barukčić
KEYWORDS:
Epstein-Barr Virus, Hodgkin’s Lymphoma, Causal Relationship
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.6 No.1,
January
26,
2018
ABSTRACT: Objective: Epstein-Barr virus
(EBV), a herpes virus which persists in memory B cells in the peripheral blood
for the lifetime of a person, is accused to be associated with several
malignancies. Hodgkin’s lymphoma (HL) has long been suspected to have an
Epstein-Barr virus infection as a causal agent. Some recent studies identified
an EBV latent infection to a high degree in Hodgkin’s lymphoma. However,
despite intensive study, the role of Epstein-Barr virus infection in Hodgkin
lymphoma remains enigmatic. Methods: To explore the cause-effect
relationship between EBV and HL and so to understand the role of EBV in HL
etiology more clearly, a systematic review and re-analysis of studies published
is performed. The method of the conditio per quam relationship was used to
proof the hypothesis if Epstein-Barr virus infection (DNA) in human lymph nodes
is present then Hodgkin lymphoma is present too. The mathematical formula of
the causal relationship k was used to proof the hypothesis, whether there is a
cause effect relationship between an Epstein-Barr virus infection (EBV DNA) and
Hodgkin lymphoma. Significance was indicated by a p-value of less than 0.05. Result: The data analyzed support the Null-hypotheses that if Epstein-Barr virus
infection (EBV DNA) is present in human lymph nodes then Hodgkin lymphoma is
present too. In the same respect, the studies analyzed provide highly
significant evidence that Epstein-Barr virus the cause of Hodgkin lymphoma. Conclusion: The findings of this study suggest that Epstein-Barr virus is the cause of
Hodgkin’s lymphoma besides of the complexity of Hodgkin’s disease.
Related Articles:
-
John Nwangwu, Ivan Roland, David Mbelwa, Cassian Magori, Marian Evans, Cynthia Price
-
Fida Medina
-
Naresh Kumar Nagwani, Shrish Verma
-
Carlos Portela, Alexandre Vasconcelos, Antônio Silva, Elder Silva, Mariano Gomes, Maurício Ronny, Wallace Lira, Sandro Oliveira
-
Bérénice Dégboé, Christiane Koudoukpo, Mouhaéminath Alimi, Ghislain Emmanuel Sopoh, Fabrice Akpadjan, Roch Christian Johnson, Nadège Agbéssi, Hugues Adégbidi, Félix Atadokpèdé