Dr. Paul E.
Sijens
University
Medical Center Groningen, Netherlands
Email:
p.e.sijens@umcg.nl
Qualifications
1988 Ph.D.,
Rijksuniversiteit Utrecht
Publications
(selected)
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Baron P,
Dorrius MD, Kappert P, Oudkerk M, Sijens PE. Diffusion-weighted imaging of
normal fibroglandular breast tissue: influence of microperfusion and fat
suppression technique on the apparent diffusion coefficient. NMR Biomed in
press 4. 329
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Sijens PE,
Dorrius MD, Kappert P, Baron P, Pijnappel RM, Oudkerk M. Quantitative
multivoxel proton CSI of the breast. Magn Reson imaging in press 1. 871
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Sijens PE,
Dorrius MD. Spectroscopic imaging in breast cancer. Imaging Decis MRI in Press
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Sijens PE.
Letter to the Editor re: Andrés Server, et al., “Proton magnetic resonance
spectroscopy in the distinction of high-grade cerebral gliomas from single
metastatic brain tumors”. Acta Radiol in Press 1. 091
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Sijens PE,
Edens MA, Bakker SHL, Stolk RP. MRI determined fat content of human liver,
pancreas and kidney. Word J Gastroentrol in press 2. 081
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Viddeleer AR,
Sijens PE, van Ooijen PMA, Kuypers PDL, Hovius SER, Oudkerk M. MR intensity
measurements of non-denervated muscle in patients following severe forearm
trauma. NMR Biomed in press 4.329
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Verbruggen KT,
Meiners LC, Sijens PE, Lunsing RJ, van Spronsen FJ, Brouwer OF. Magnetic
resonance imaging and proton magnetic resonance spectroscopy in the diagnostic
evaluation of developmental delay. Eur J Pediatr Neurol 2009;13:181-190 1. 421
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Dikkers R,
Greuter MJW, Kristanto W, van Ooijen PMA, Sijens PE, Willems TP, Oudkerk M. The
assessment of image quality of 64-row dual source versus single source CT
coronary angiography on heart rate: a phantom study. Eur J Radiol
2009;70:61-68 2. 339
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Olthof AW,
Sijens PE, Kreeftenberg HG, Kappert P, van der Jagt EJ, Oudkerk M. Non-invasive
liver iron concentration measurement by MRI: comparison of two validated
protocols. Eur J Radiol 2009;71:116-21 2. 339
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Viddeleer AR,
Sijens PE, van Ooijen PMA, Kuypers PDL, Hovius SER, Oudkerk M. Long term
reproducibility of phantom image intensities in nonouniformity corrected
STIR-MRI examinations of skeletal muscle. Magn Reson Mater Phy
2009;22:201-209 1. 844
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Edens MA, van
Ooijen PMA, Post WJ, Haagmans MJF, Kristanto W, Sijens PE, van der Jagt EJ,
Stolk RP. Ultrasonography to quantify hepatic fat content: validation by 1H
Magnetic Resonance Spectroscopy. Obesity 2009;17:2239-2244 2. 762
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Sijens PE,
Westerlaan HE, de Groot JC, Boon M, Potze JH, van Spronsen FJ, Lunsing RJ,
Oudkerk M. MR spectroscopy of diffusion tensor imaging of the brain in
Sjögren-Larsson syndrome. Mol Genet Metab 2009;98:167-171 2. 629
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Sijens PE.
Parametric exploration of the liver by magnetic resonance methods. Eur Radiol
2009;19:2594-2607 3. 651
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Sijens PE,
Lubbers DD. Comparison of two fast MRI methods for perfusion imaging of the
heart. Imaging Decis MRI 2009;13:43-48
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Verbruggen KT,
Maurits NM, van Spronsen FJ, Brouwer OF, Sijens PE. Quantitative multivoxel
proton spectroscopy of the brain in developmental delay. J Magn Reson Imaging
2009;30:716-721 2. 658
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Sijens PE,
Oudkerk M, Letter to the Editor re: Richard J. Maddock et al. “Brain lactate
responses during visual stimulation in fasting and hyperglycemic subjects:
a proton magnetic resonance study at 1.5 tesla” [Psychiatry Research
Neuroimaging 2006; 148:47-54]. Psych Res Neuroim 2008;162:173-174 2. 666
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Irwan R, Edens
MA, Sijens PE. Assessment of the variations in fat content in normal liver
using a fast quantification: MR imaging method in comparison with results
obtained by spectroscopic imaging. Eur Radiol 2008;18:806-813 3. 651
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Sijens PE,
Mostert JP, Irwan R, Potze JH, Oudkerk M, De Keyser, J. The impact of
fluoxetine on the human brain in multiple sclerosis as quantified by 1H MR
Spectroscopy and diffusion tensor imaging: preliminary findings. Psych Res
Neuroim 2008;174:274-282 2. 666
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Sijens PE,
Smit GPA, Rödiger LA, van Spronsen FJ, Oudkerk M, Rodenburg RJ, Lunsing RJ. MR
Spectroscopy of the brain in Leigh syndrome. Brain Dev 2008;30:579-83 1.
414
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Borra R,
Lautamäki R, Parkkola R, Komu M, Sijens PE, Hälsten K, Bergman J, Iozzo P,
Nuutila P. Inverse association between liver fat content and hepatic glucose
uptake in patients with type 2 diabetes. Metab Clin Exper
2008;57:1445-1451 2. 920
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Sijens PE,
Rödiger LA, Meiners LC, Lunsing RJ. 1H magnetic resonance spectroscopy in
monocarboxylate transporter 8 gene deficiency. J Clin Endocrin
Metab 2008;93:1854-9 6. 32
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Sijens PE,
Alkefaji H, Lunsing RJ, van Spronsen FJ, Meiners LC, Oudkerk M, Verkade HJ.
Quantitative multivoxel MR spectroscopy of the brain in children with acute
liver failure. Eur Radiol 2008;18:2601-2609 3. 651
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Irwan R, de
Vries HBK, Sijens PE. The impact of scan length on the exposure levels in
16-row MSCT and 64-row MSCT: a phantom study. Acad Radiol 2008;15: 1142-7 2.
021
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Olthof AW,
Sijens PE, Kreeftenberg HG, Kappert P, Irwan R, van der Jagt EJ, Oudkerk M. The
impact of hematologic disease and inflammation on the relationship between
liver iron concentration as determined by magnetic resonance imaging and serum
ferritin concentration. Magn Reson Imaging 2007;25:228-231 1. 871
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Irwan R,
Lubbers DD, van der Vleuten PA, Kappert P, Gotte MJ, Sijens PE. Parallel
imaging for first-pass myocardial perfusion. Magn Reson Imaging 2007;5:678-683
1. 871
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Sijens PE,
Fock JM, Meiners LC, Potze JH, Irwan R, Oudkerk M. MR spectroscopy and
diffusion tensor imaging of the brain in congenital muscular dystrophy with
merosin deficiency: metabolite level decreases, fractional anisotropy
decreases, and apparent diffusion coefficient increases in the white matter.
Brain Dev 2007;19:317-321 1. 401
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Verbruggen KT,
Knijff WA, Lunsing RJ, Hordijk R, Sijens PE, Verhoeven NM, Salomons GS,
Goorhuis-Brouwer SM, van Spronsen FJ. GAMT deficiency causing global
developmental delay: differences between formal testing and clinical
observation. Eur J Pediatr 2007;166:921-925 1. 416
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Verbruggen KT,
Sijens PE, Schulze A, Lunsing RJ, Jacobs C, Salomons GS, van Spronsen FJ.
Successfull treatment of a guanidinoacetate methyltransferase deficient
patient: findings with relevance to treatment strategy and pathofysiology. Mol
Genet Metab 2007;91:294-296 2. 629
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van Oostrum
JCH, Sijens PE, Roos RAC, Leenders KL. 1H magnetic resonance spectroscopy in
preclinical Huntington disease. Brain Res 2007;1168;67-71 2. 494
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Sijens PE,
Heesters MAAM, Enting RH, Potze JH, Irwan R, Meiners LC, Oudkerk M. Diffusion
tensor imaging and chemical shift imaging assessment of heterogeneity in
astrocytoma under temozolomide chemotherapy Cancer Invest
2007;25:706-710 1. 976