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has been cited by the following article:

• TITLE: Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from Taxodium distichum Cones

  AUTHORS: Norihisa Kusumoto, Nobuhiro Aburai, Tatsuya Ashitani, Koetsu Takahashi, Ken-ichi Kimura

  KEYWORDS: Abietane Diterpenoid; Conifer Cone; Antibacterial Activity; 17α-Hydroxylase/C17, 20-Lyase; Prolyl Oligopeptidase; Cytotoxicity

  JOURNAL NAME: Advances in Biological Chemistry, Vol.4 No.2, March 31, 2014

  ABSTRACT: Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distichum cones and their biological properties evaluated in vitro against six different biological screening targets. Taxodione showed potent activity against a number of different targets, and salvinolone and 14-deoxycoleon U showed remarkable inhibitory activities against prolyl oligopeptidase (POP) and 17α-hydroxylase/C17,20-lyase (CYP17), respectively. These three compounds also showed strong cytotoxic activities against HL60 and K562 human leukemia cells. The structure-activity relationships of these compounds have also been considered. The findings in this study could lead to enhanced pharmacological prospects for the natural abietane-type diterpenoids consisting in conifer cones.