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The Unexplored Role of Probiotics on the Parasitic Pathogens

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DOI: 10.4236/fns.2014.522230    4,176 Downloads   5,329 Views   Citations

ABSTRACT

The beneficial bacteria coined as probiotics are used as therapeutics to the host and evidences are there to demonstrate to treat bacterial and viral respiratory infections, gastrointestinal diseases, eczema, inflammation, H. pylori infection, irritable bowel syndrome and allergic symptoms etc. In recent past, probiotics has been reported for the control of intestinal parasite infections as well as few non-gut infections spread among human and veterinary animals. Animal models and in vitro culture systems have been studied regarding cellular interactions between probiotics and pathogens or relevant host cells, though the underlying molecular mechanisms mediating the beneficial effects have not yet fully discovered. Hence, more evidence based studies are warranted to correlate whether probiotics through multiple mechanisms might indeed provide a strain-specific protection against parasites to use it as therapeutics. This article has described the effect of probiotics in some of the intestinal as well as non-gut parasites and suggested the scope of exploring the benefit for protozoan parasite Leishmania, as India is planning for the elimination of the disease.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Mukhopadhyay, B. and Ganguly, N. (2014) The Unexplored Role of Probiotics on the Parasitic Pathogens. Food and Nutrition Sciences, 5, 2177-2184. doi: 10.4236/fns.2014.522230.

References

[1] Gueimonde, M. and Collado, M.C. (2012) Metagenomics and Probiotics. Clinical Microbiology and Infection, 18, 32-34.
http://dx.doi.org/10.1111/j.1469-0691.2012.03873.x
[2] Ghosh, T.S., Gupta, S.S., Nair, G.B. and Mande, S.S. (2013) In Silico Analysis of Antibiotic Resistance Genes in the Gut Microflora of Individuals from Diverse Geographies and Age-Groups. PloS One, 8, e83823.
http://dx.doi.org/10.1371/journal.pone.0083823
[3] Food and Agriculture Organization of the United Nations, World Health Organization (2002) Guidelines for the Evaluation of Probiotics in Food. Report of a Joint FAO/WHO Working Group on Drafting Guidelines for Evaluation of Probiotics in Food, London Ontario, Canada, Apr. 30 & May 1.
http://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf
[4] Gupta, V. and Garg, R. (2009) Probiotics. Indian Journal of Medical Microbiology, 27, 202-209.
http://dx.doi.org/10.4103/0255-0857.53201
[5] Travers, M.A., Florent, I., Kohl, L. and Grellier, P. (2011) Probiotics for the Control of Parasites: An Overview. Journal of Parasitology Research, 2011, Article ID: 610769.
[6] Wohlgemuth, S., Loh, G. and Blaut, M. (2010) Recent Developments and Perspectives in the Investigation of Probiotic Effects. International Journal of Medical Microbiology, 300, 3-10.
http://dx.doi.org/10.1016/j.ijmm.2009.08.003
[7] Glass, M.D., Courtney, P.D., LeJeune, J.T. and Ward, L.A. (2004) Effects of Lactobacillus acidophilus and Lactobacillus reuteri Cell-Free Supernatants on Cryptosporidium Viability and Infectivity in Vitro. Food Microbiology, 21, 423-429.
http://dx.doi.org/10.1016/j.fm.2003.11.001
[8] Foster, J.C., Glass, M.D., Courtney, P.D. and Ward, L.A. (2003) Effect of Lactobacillus and Bifidobacterium on Cryptosporidium parvum Oocyst Viability. Food Microbiology, 20, 351-357.
http://dx.doi.org/10.1016/S0740-0020(02)00120-X
[9] Alak, J.I., Wolf, B.W., Mdurvwa, E.G., Pimentel-Smith, G.E., Kolavala, S., Abdelrahman, H. and Suppiramaniam, V. (1999) Supplementation with Lactobacillus reuteri or L. acidophilus Reduced Intestinal Shedding of Cryptosporidium parvum Oocysts in Immunodeficient C57bl/6 Mice. Cellular and Molecular Biology, 45, 855-863.
[10] Alak, J.I., Wolf, B.W., Mdurvwa, E.G., Pimentel-Smith, G.E. and Adeyemo, O. (1997) Effect of Lactobacillus reuteri on Intestinal Resistance to Cryptosporidium parvum Infection in a Murine Model of Acquired Immunodeficiency Syndrome. The Journal of Infectious Diseases, 175, 218-221.
http://dx.doi.org/10.1093/infdis/175.1.218
[11] Waters, W.R., Harp, J.A., Wannemuehler, M.J., Carbajal, N.Y. and Casas, I.A. (1999) Effects of Lactobacillus reuteri on Cryptosporidium parvum Infection of Gnotobiotic Tcr-Alpha-Deficient Mice. The Journal of Eukaryotic Microbiology, 46, 60S-61S.
[12] Pickerd, N. and Tuthill, D. (2004) Resolution of Cryptosporidiosis with Probiotic Treatment. Postgraduate Medical Journal, 80, 112-113.
http://dx.doi.org/10.1136/pmj.2003.014175
[13] Harp, J.A., Jardon, P., Atwill, E.R., Zylstra, M., Checel, S., Goff, J.P. and De Simone, C. (1996) Field Testing of Prophylactic Measures against Cryptosporidium Parvum Infection in Calves in a California Dairy Herd. American Journal of Veterinary Research, 57, 1586-1588.
[14] Deng, M., Nuanualsuwan, S. and Cliver, D.O. (2001) Inactivation of Cryptosporidium parvum Oocysts by Bacterial Strains. The Journal of Eukaryotic Microbiology, 48, 37S-39S.
http://dx.doi.org/10.1111/j.1550-7408.2001.tb00446.x
[15] Guitard, J., Menotti, J., Desveaux, A., Alimardani, P., Porcher, R., Derouin, F. and Kapel, N. (2006) Experimental Study of the Effects of Probiotics on Cryptosporidium parvum Infection in Neonatal Rats. Parasitology Research, 99, 522-527.
http://dx.doi.org/10.1007/s00436-006-0181-4
[16] Benyacoub, J., Perez, P.F., Rochat, F., Saudan, K.Y., Reuteler, G., Antille, N., Humen, M., De Antoni, G.L., Cavadini, C., Blum, S. and Schiffrin, E.J. (2005) Enterococcus faecium SF68 Enhances the Immune Response to Giardia intestinalis in Mice. The Journal of Nutrition, 135, 1171-1176.
[17] Shukla, G. and Sidhu, R.K. (2011) Lactobacillus casei as a Probiotic in Malnourished Giardia Lamblia-Infected Mice: A Biochemical and Histopathological Study. Canadian Journal of Microbiology, 57, 127-135.
http://dx.doi.org/10.1139/W10-110
[18] Shukla, G., Devi, P. and Sehgal, R. (2008) Effect of Lactobacillus casei as a Probiotic on Modulation of Giardiasis. Digestive Diseases and Sciences, 53, 2671-2679.
http://dx.doi.org/10.1007/s10620-007-0197-3
[19] Humen, M.A., De Antoni, G.L., Benyacoub, J., Costas, M.E., Cardozo, M.I., Kozubsky, L., Saudan, K.Y., Boenzli-Bruand, A., Blum, S., Schiffrin, E.J. and Perez, P.F. (2005) Lactobacillus johnsonii La1 Antagonizes Giardia intestinalis in Vivo. Infection and Immunity, 73, 1265-1269.
http://dx.doi.org/10.1128/IAI.73.2.1265-1269.2005
[20] Perez, P.F., Minnaard, J., Rouvet, M., Knabenhans, C., Brassart, D., De Antoni, G.L. and Schiffrin, E.J. (2001) Inhibition of Giardia intestinalis by Extracellular Factors from Lactobacilli: An in Vitro Study. Applied and Environmental Microbiology, 67, 5037-5042.
http://dx.doi.org/10.1128/AEM.67.11.5037-5042.2001
[21] Obendorf, J., Renner Viveros, P., Fehlings, M., Klotz, C., Aebischer, T. and Ignatius, R. (2013) Increased Expression of CD25, CD83, and CD86, and Secretion of Il-12, Il-23, and Il-10 By Human Dendritic Cells Incubated in the Presence of Toll-Like Receptor 2 Ligands and Giardia duodenalis. Parasites & Vectors, 6, 317.
http://dx.doi.org/10.1186/1756-3305-6-317
[22] Solano-Aguilar, G., Shea-Donohue, T., Madden, K., Dawson, H., Ledbetter, T., Urban, J.J. and Gasbarre, L.C., Eds. (2004) The Effect of Human-Derived Probiotic Bacteria on the Intestinal Function of Pigs. (Veterinary Parasitology), Symposium: New Approaches in the Study of Animal Parasites, 125, 147-161.
[23] de Fátima Macedo Santos, J., Vasconcelos, J., de Souza, J.R., de Medeiros Coutinho, E., Montenegro, S.M. and Azevedo-Ximenes, E. (2004) The Effect of Zymomonas mobilis Culture on Experimental Schistosoma mansoni Infection. Revista da Sociedade Brasileira de Medicina Tropical, 37, 502-504.
http://dx.doi.org/10.1590/S0037-86822004000600015
[24] Tierney, J., Gowing, H., Van Sinderen, D., Flynn, S., Stanley, L., McHardy, N., Hallahan, S. and Mulcahy, G. (2004) In Vitro Inhibition of Eimeria tenella Invasion by Indigenous Chicken Lactobacillus Species. Veterinary Parasitology, 122, 171-182.
http://dx.doi.org/10.1016/j.vetpar.2004.05.001
[25] Lee, S.H., Lillehoj, H.S., Dalloul, R.A., Park, D.W., Hong, Y.H. and Lin, J.J. (2007) Influence of Pediococcus-Based Probiotic on Coccidiosis in Broiler Chickens. Poultry Science, 86, 63-66.
http://dx.doi.org/10.1093/ps/86.1.63
[26] Dalloul, R.A., Lillehoj, H.S., Shellem, T.A. and Doerr, J.A. (2003) Enhanced Mucosal Immunity against Eimeria Acervulina in Broilers Fed a Lactobacillus-Based Probiotic. Poultry Science, 82, 62-66.
http://dx.doi.org/10.1093/ps/82.1.62
[27] Dalloul, R.A., Lillehoj, H.S., Tamim, N.M., Shellem, T.A. and Doerr, J.A. (2005) Induction of Local Protective Immunity to Eimeria acervulina by a Lactobacillus-Based Probiotic. Comparative Immunology, Microbiology and Infectious Diseases, 28, 351-361.
http://dx.doi.org/10.1016/j.cimid.2005.09.001
[28] Dalloul, R.A., Lillehoj, H.S., Shellem, T.A. and Doerr, J.A. (2003) Intestinal Immunomodulation by Vitamin A Deficiency and Lactobacillus-Based Probiotic in Eimeria acervulina-Infected Broiler Chickens. Avian Diseases, 47, 1313-1320.
http://dx.doi.org/10.1637/6079
[29] Lee, S., Lillehoj, H.S., Park, D.W., Hong, Y.H. and Lin, J.J. (2007) Effects of Pediococcus- and Saccharomyces-Based Probiotic (MitoMax?) on Coccidiosis in Broiler Chickens. Comparative Immunology, Microbiology and Infectious Diseases, 30, 261-268.
http://dx.doi.org/10.1016/j.cimid.2007.02.002
[30] Basualdo, J., Sparo, M., Chiodo, P., Ciarmela, M. and Minvielle, M. (2007) Oral Treatment with a Potential Probiotic (Enterococcus faecalis Cect 7121) Appears to Reduce the Parasite Burden of Mice Infected with Toxocara canis. Annals of Tropical Medicine and Parasitology, 101, 559-562.
http://dx.doi.org/10.1179/136485907X193824
[31] Bautista-Garfias, C.R., Ixta-Rodriguez, O., Martinez-Gomez, F., Lopez, M.G. and Aguilar-Figueroa, B.R. (2001) Effect of Viable or Dead Lactobacillus casei Organisms Administered Orally to Mice on Resistance Against Trichinella spiralis Infection. Parasite, 8, S226-S228.
http://dx.doi.org/10.1051/parasite/200108s2226
[32] Kato, I., Tanaka, K. and Yokokura, T. (1999) Lactic Acid Bacterium Potently Induces the Production of Interleukin-12 and Interferon-Gamma by Mouse Splenocytes. International Journal of Immunopharmacology, 21, 121-131.
http://dx.doi.org/10.1016/S0192-0561(98)00072-1
[33] Martinez-Gomez, F., Ixta-Rodriguez, O., Aguilar-Figueroa, B., Hernandez-Cruz, R. and Monroy-Ostria, A. (2006) Lactobacillus casei ssp. Rhamnosus Enhances Nonspecific Protection against Plasmodium chabaudi AS in Mice. Salud Publica de Mexico, 48, 498-503.
http://dx.doi.org/10.1590/S0036-36342006000600008
[34] Bautista, C.R., Sandoval, A. and Aguilar, B.R. (2008) Effect of High- and Low-Molecular-Weight Components of Lactobacillus casei on Resistance against Babesia microti in NIH Mice. Annals of the New York Academy of Sciences, 1149, 152-154.
http://dx.doi.org/10.1196/annals.1428.037
[35] Bautista-Garfias, C.R., Gomez, M.B., Aguilar, B.R., Ixta, O., Martinez, F. and Mosqueda, J. (2005) The Treatment of Mice with Lactobacillus casei Induces Protection against Babesia microti Infection. Parasitology Research, 97, 472-477.
http://dx.doi.org/10.1007/s00436-005-1475-7
[36] Garfias, C.R.B., álvarez, M.C.T. and Gómez, F.M. (2008) The Inoculation of Lactobacillus casei in NIH Mice Induces a Protective Response against Trypanosoma cruzi (Ninoa Strain) Infection. Veterinaria Mexico, 39, 139-144.
[37] Eze, J.I., Orajaka, L.J., Okonkwo, N.C., Ezeh, I.O., Ezema, C. and Anosa, G.N. (2012) Effect of Probiotic (Saccharomyces cerevisiae) Supplementation on Immune Response in Trypanosoma Brucei Brucei Infected Rats. Experimental Parasitology, 132, 434-439.
http://dx.doi.org/10.1016/j.exppara.2012.09.021
[38] McClemens, J., Kim, J.J., Wang, H., Mao, Y.K., Collins, M., Kunze, W., Bienenstock, J., Forsythe, P. and Khan, W.I. (2013) Lactobacillus rhamnosus Ingestion Promotes Innate Host Defense in an Enteric Parasitic Infection. Clinical and Vaccine Immunology, 20, 818-826.
http://dx.doi.org/10.1128/CVI.00047-13
[39] Mansour-Ghanaei, F., Dehbashi, N., Yazdanparast, K. and Shafaghi, A. (2003) Efficacy of Saccharomyces boulardii with Antibiotics in Acute Amoebiasis. World Journal of Gastroenterology, 9, 1832-1833.
[40] Goff, W.L., Johnson, W.C., Tuo, W., Valdez, R.A., Parish, S.M., Barrington, G.M. and Davis, W.C. (2002) Age-Related Innate Immune Response in Calves to Babesia bovis Involves IL-12 Induction and IL-10 Modulation. Annals of the New York Academy of Sciences, 969, 164-168.
http://dx.doi.org/10.1111/j.1749-6632.2002.tb04371.x
[41] Galdeano, C.M. and Perdigon, G. (2006) The Probiotic Bacterium Lactobacillus casei Induces Activation of the Gut Mucosal Immune System through Innate Immunity. Clinical and Vaccine Immunology, 13, 219-226.
http://dx.doi.org/10.1128/CVI.13.2.219-226.2006
[42] Oliveira, A.C., Peixoto, J.R., de Arruda, L.B., Campos, M.A., Gazzinelli, R.T., Golenbock, D.T., Akira, S., Previato, J.O., Mendonca-Previato, L., Nobrega, A. and Bellio, M. (2004) Expression of Functional TLR4 Confers Proinflammatory Responsiveness to Trypanosoma cruzi Glycoinositolphospholipids and Higher Resistance to Infection with T. cruzi. Journal of Immunology, 173, 5688-5696.
http://dx.doi.org/10.4049/jimmunol.173.9.5688
[43] Oliva-Teles, A. (2012) Nutrition and Health of Aquaculture Fish. Journal of Fish Diseases, 35, 83-108.
http://dx.doi.org/10.1111/j.1365-2761.2011.01333.x
[44] Walden, M. (2012) Evaluation of Three Treatment Modalities against Isospora amphiboluri in Inland Bearded Dragons (Pogna Vitticeps). Journal of Exotic Pet Medicine, 21, 213-218.
http://dx.doi.org/10.1053/j.jepm.2012.06.008
[45] Bybee, S.N., Scorza, A.V. and Lappin, M.R. (2011) Effect of the Probiotic Enterococcus faecium SF68 on Presence of Diarrhea in Cats and Dogs Housed in an Animal Shelter. Journal of Veterinary Internal Medicine, 25, 856-860.
http://dx.doi.org/10.1111/j.1939-1676.2011.0738.x
[46] Das, G., Atasoglu, C., Akbag, H.I., Tolu, C., Yurtman, I.Y. and Savas, T. (2012) Effects of Kefir on Coccidial Oocysts Excretion and Performance of Dairy Goat Kids Following Weaning. Tropical Animal Health and Production, 44, 1049-1055.
http://dx.doi.org/10.1007/s11250-011-0039-3
[47] WHO Regional Office for South-East Asia (2011) Epidemiological Information on Disease Burden Due to Kala-Azar in Bangladesh, India and Nepal. Report of an Informal Consultation, Paro.
[48] Gupta, A., Nagar, M., Mishra, S.S. and Lahariya, C. (2013) Visceral Leishmaniasis (Kala-Azar) Elimination from Indian Sub-Continent by 2015? International Journal Tropical Diseases and Health, 3, 73-81.
http://dx.doi.org/10.9734/IJTDH/2013/2732

  
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