Author(s)

Hiroi Tomioka^1,2, Junichi Masuda³, Akikazu Takada^4*, Akira Iwanami¹

¹Department of Psychiatry, Showa University School of Medicine, Showa, Japan.
²Department of Psychiatry, Showa University Northern Yokohama Hospital, Showa, Japan.
³Global Application Development Center, Shimadzu Corporation, Kanagawa-ken, Japan.
⁴International Projects on Food and Health (NPO), Tokyo, Japan.

Background: No research has been done for the determination of plasma levels of tryptophan metabolites in patients of monopolar and bipolar depression. Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: No significant age and gender differences were shown in monopolar depressive patients and some differences were shown in bipolar patients. The administration of drugs such as antidepressants, antipsychotics, mood stabilizers do not seem to have affected the results. Conclusion: In patients of major monopolar depression age and gender differences of plasma levels of tryptophan metabolites disappear although significant differences are observed in healthy volunteers. Some differences of age and gender differences were shown between monopolar and bipolar depressive patients.

Depression, Monopolar Depression, Bipolar Depression, Tryptophan, Serotonin, 5-Hydroxyindole Acetic Acid, Kynurenine, 3-Hydroxykynurenine, Kynurenic Acid, Anthranilic Acid, Xanthurenic Acid, Indole-3-Acetic Acid, SSRI (Selective Serotonin Reuptake Inhibitor), SNRI (Serotonin Norepinephrine Reuptake Inhibitor), Anxiolytic, Antipsychotic

Tomioka, H. , Masuda, J. , Takada, A. and Iwanami, A. (2020) Comparison of Age and Gender Differences of Tryptophan Metabolites in Patients of Major Monopolar and Bipolar Depression. Food and Nutrition Sciences, 11, 172-185. doi: 10.4236/fns.2020.113013.