The Role of Reaction Engineering in Cancer Biology: Bio-Imaging Informatics Reveals Implications of the Plasma Membrane Heterogeneities

DOI:                 

Abstract

Recent developments in microscopy have led to revolutionary advances in our knowledge of the spatiotemporal dynam-ics of proteins in the plasma membrane of living cells and of heterogeneity of the plasma membrane. For example, spa-tial heterogeneities in the epidermal growth factor (EGF) receptor (EGFR) distribution in different domains of the plasma membrane are becoming increasingly evident. However, the influence of these heterogeneities on cellular sig-naling remains elusive despite uncontrolled receptor signaling being implicated in various forms of cancer. Herein, we suggest a reaction engineering, multiscale simulation framework, coined as model based bio-imaging informatics. This framework can fill in the scales’ gap between various experimental methods and analyze the wealth of image informat-ics to unravel the influence of plasma membrane heterogeneities on the early events of the EGFR signaling, namely EGF binding and EGFR dimerization. An overarching conclusion arising from our work is that the plasma membrane heterogeneities can strongly modulate the amount as well the mechanism of ligand–receptor binding.

Keywords

multiscale modeling, kinetic monte carlo, receptors, diffusion, imaging, informatics, cancer

Conflicts of Interest

The authors declare no conflicts of interest.

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