Post Radiotherapy “Isolated LP of the Lips” in a Non-Hodgkin Lymphoma Patient: A Possible Relation 237
Diagram 1. Cancer-radiotherapy-lichen planus-triangle; the
key ward is possibly the T-lymphocyte which gets disrupted
in-between the sharp angles.
Gulf countries, but it may be underestimated and under
reported. Doctors should be aware that neoplasms and/or
radiotherapy for neoplasms may induce OLP and OLP
may transform, this mandates awareness by the radiolo-
gist to focus their radiation beam as far as possible far
from the mucosae; it is fragile and may get easily trapped
in LP. Further research is required to elucidate the inter-
relations in the cancer-radiotherapy-LP triangle; the key
ward is possibly the T lymphocyte which gets disrupted
in between the sharp angles (Diagram 1).
REFERENCES
[1] R. A. Safadi, S. Z. Al Jaber, H. M. Hammad and A. A.
Hamasha, “Oral Lichen Planus Shows Higher Expres-
sions of Tumor Suppressor Gene Products of p53 and p21
Compared to Oral Mucositis. An Immunohistochemical
Study,” Archives of Oral Biology, Vol. 55, No. 6, 2010,
pp. 454-461. doi:10.1016/j.archoralbio.2010.03.019
[2] P. H. Itin, P. Schiller, L. Gilli and S. A. Buechner, “Iso-
lated Lichen Planus of the Lip,” British Journal of Der-
matology, Vol. 132, No. 6, 1995, pp. 1000-1002.
doi:10.1111/j.1365-2133.1995.tb16963.x
[3] D. Eisen, “The Clinical Features, Malignant Potential,
and Systemic Associations of Oral Lichen Planus: A Stu-
dy of 723 Patients,” Journal of the American Academy of
Dermatology, Vol. 46, No. 2, 2002, pp. 207-214.
doi:10.1067/mjd.2002.120452
[4] F. Lozada-Nur and C. Miranda, “Oral Lichen Planus: Epi-
demiology Clinical Characteristics, and Associated Dis-
eases,” Seminars in Cutaneous Medicine and Surgery,
Vol. 16, No. 4, 1997, pp. 273-277.
doi:10.1016/S1085-5629(97)80016-8
[5] S. Silverman and S. Bahl, “Oral Lichen Planus Update:
Clinical Characteristics, Treatment Responses, and Ma-
lignant Transformation,” American Journal of Dentistry,
Vol. 10, No. 6, 1997, pp. 259-263.
[6] S. J. R. Alan and P. K. Buxon, “Isolated Lichen Planus of
the Lip,” British Journal of Dermatology, Vol. 135, No. 1,
1996, pp. 145-146.
doi:10.1111/j.1365-2133.1996.tb03631.x
[7] D. Eisen, “The Vulvovaginal-Gengival Syndrome of Li-
chen Planus, the Clinical Characteristics of 22 Cases,” Ar-
chives of Dermatology, Vol. 130, No. 11, 1994, pp. 1379-
1382. doi:10.1001/archderm.1994.01690110045004
[8] L. P. Fox, C. J. Lightdale and M. E. Grossman, “Lichen
Planus of the Esophagus: What Dermatologists Need to
Know,” Journal of the American Academy of Dermatol-
ogy, Vol. 65, No. 1, 2011, pp. 175-183.
doi:10.1016/j.jaad.2010.03.02 9 .
[9] Y. X. Pan, Y. Cai and H. B. Yu, “Expression of Inter-
leukin-12p40 and Interferon-Gamma in Local Lesions of
Human Oral Lichen Planus,” West China Journal of Sto-
matology, Vol. 29. No. 2, 2011, pp. 179-182.
[10] A. Sun, J. T. Wang, J. S. Chia and C. P. Chiang, “Serum
Interleukin-8 Level Is a More Sensitive Marker than Se-
rum Interleukin-6 Level in Monitoring the Disease Activ-
ity of Oral Lichen Planus,” British Journal of Dermatol-
ogy, Vol. 152, 2005, pp. 1187-1192.
doi:10.1111/j.1365-2133.2005.06497.x
[11] Y. Zhang, W. Liu, S. Zhang, H. Dan, R. Lu, F. Wang, J.
Wang, M. Zhou, X. Zeng, M. Lin, Q. Chen and Y. Zhou,
“Salivary and Serum Interleukin-18 in Patients with Oral
Lichen Planus: A Study in an Ethnic Chinese Population,”
Inflammation, Vol. 35, No. 2, 2012, pp. 399-404.
[12] M. Carbone, P. G. Arduino, M. Carrozzo, S. Gandolfo, M.
R. Argiolas, G. Bertolusso, D. Conrotto, M. Pentenero and
R. Broccoletti, “Course of Oral Lichen Planus: A Retro-
spective Study of 808 Northern Italian Patients,” Oral
Diseases, Vol. 15, No. 3, 2009, pp. 235-243.
doi:10.1111/j.1601-0825.2009.01516.x
[13] S. Petti, M. Rabiei, M. De Luca and C. Scully, “The Mag-
nitude of the Association between Hepatitis C Virus In-
fection and Oral Lichen Planus: Meta-Analysis and Case
Control Study,” Odontology, Vol. 99, No. 2, 2011, pp. 168-
178. doi:10.1007/s10266-011-0008-3
[14] J. Qiao, G. Zhou, Y. Ding, D. Zhu and H. Fang, “Multiple
Paraneoplastic Syndromes: Myasthenia Gravis, Vitiligo,
Alopecia Areata, and Oral Lichen Planus Associated with
Thymoma,” Journal of the Neurological Sciences, Vol.
308, No. 1, 2011, pp. 177-179.
doi:10.1016/j.jns.2011.05.038
[15] Y. Kaku, N. Shimamoto, H. Matsunaga, M. Makiura, A.
Fujisawa and K. Morita, “Oral Erosive Lichen Planus and
Alopecia Areata with Good’s Syndrome (Thymoma with
Hypogammaglobulinemia),” European Journal of Der-
matology, Vol. 21, No. 1, 2011, pp. 124-125.
[16] V. Mahler, C. Antoni, G. J. Anhalt, H. J. Koch, K. P. Pe-
ters, B. Manger, et al., “Graft-versus-Host-Like Mucocu-
taneous Eruptions with Serological Features of Paraneo-
plastic Pemphigus and Systemic Lupus Erythematosus in
a Patient with Non-Hodgkin’s Lymphoma,” Dermatology,
Vol. 197, No. 1, 1998, pp. 78-83. doi:10.1159/000017964
[17] C. J. Hsiao, M. M. Hsu, J. Y. Lee, W. C. Chen and W. C.
Hsieh, “Paraneoplastic Pemphigus in Association with a
Retroperitoneal Castleman’s Disease Presenting with a
Lichen Planuspemphigoides-Like Eruption. A Case Re-
port and Review of Literature,” British Journal of Der-
matology, Vol. 144, No. 2, 2001, pp. 372-376.
doi:10.1046/j.1365-2133.2001.04030.x
[18] S. Poomsawat, W. Buajeeb, S. O. Khovidhunkit and J.
Copyright © 2012 SciRes. JCDSA