The acceleration in the rate of chronic disease that involves insulin resistance has become of concern in various countries. The rate of the most prevalent chronic diseases involves the metabolic syndrome and non alcoholic fatty liver disease (NAFLD) that is closely associated to diabetes and neurodegenerative diseases. Biotherapeutics and nutritional biotherapy have become important to reverse these global diseases. Biotherapeutics that involves Indian spice therapy requires assessment with relevance to insulin therapy, immunotherapy, antimicrobial therapy and drug therapeutics. Combined insulin therapy and Indian spice therapy regulates human insulin biological activity with relevance to the prevention of uncontrolled intracellular glucose levels and mitochondrial apoptosis. Biotherapeutics with nutritional biotherapy that involves the use of various nutrients such as magnesium and phosphatidylinositol (gm/day) is essential to insulin therapy. Factors such as stress, core body temperature and food quality influence biotherapeutics and Indian spice therapy with delayed spice clearance associated with mitochondrial dysfunction (cell apoptosis) and altered drug/caffeine therapy with relevance to the global diabetes pandemic.
Biotherapeutics has become of importance to global chronic diseases to prevent accelerated aging associated with uncontrolled immune reactions that determine treatment and disease progression. In the global burden of disease connections between nutritional therapy and the immune system [
Indian spices have been reported to exhibit a wide range of physiological and pharmacological properties that produce beneficial health promoting/protective effects for various chronic diseases [
cinnamon and curcumin involved in the improvement of plasma hyperglycemia and involved with the regulation of insulin dose/type and frequency of use in diabetes therapeutics [
Biotherapeutics for diseases (
roles in genomic stability. Antioxidants and vitamins C, D and E are essential and maintain genomic stability. A lack of antioxidants leads to increased free radical damage and more risk for damage to telomeres essential to cell survival. Minerals such as magnesium and zinc are required for the prevention of DNA strand breakage and the prevention of accelerated cell aging. Nutrients such as quercetin, green tea catechins, grape seed extract, resveratrol and omega 3 fatty acids (eicosapen-taenoic acid/docosahexaenoic acid) are important as basic nutrients to preserve biological aging and reverse diabetes. Poor food quality [
Core body temperature connections to the immune system and mitochondrial cell function [
Biotherapeutics for chronic diseases has accelerated to prevent the progression of the current global chronic disease epidemic. Indian spice therapy has become an important biotherapeutic involved in the reversal of global diabetes and neurodegeneration. Mitophagy in chronic disease requires attention with Indian spice therapy and insulin therapy as a combined therapy to regulate cell glucose levels to prevent hyperglycemic induced mitochondrial apoptosis. Specific nutrients need to be consumed with Indian spices to allow stabilization of uncontrolled toxic reactions that lead to cell death. Core body temperature, stress and inappropriate food quality will inactivate Indian spice therapy with excessive Indian spice intake over many years that may be connected to ineffective human insulin biological activity/drug biotherapeutics with long term Indian spice use more relevant to cell apoptosis and the treatment of cancer. Monitoring of long term Indian spice therapy may be required in future clinical trials in man with relevance to safety compared to diabetic individuals with insulin therapy and without Indian spice therapy.
This work was supported by grants from Edith Cowan University, the McCusker Alzheimer’s Research Foundation and the National Health and Medical Research Council.
Martins, I.J. (2018) Indian Spices and Biotherapeutics in Health and Chronic Disease. Health, 10, 374-380. https://doi.org/10.4236/health.2018.104030