Background: Venous thromboembolism (VTE) is a major cause of morbidity and mortality worldwide. It is also the most common complication in hospitalized patients. Aims: To study the in-hospital prevalence of VTE, describe the socio-demographic characteristics of patients, determine the frequency of risk factors, describe the clinical presentations, and determine the short term outcome of VTE in hospitalized patients in a low-income tertiary hospital setting. Methods: We carried out a cross - sectional descriptive retrospective study over a period of 6 years and 4 months (January 2008 to April 2014) in the Douala General Hospital — Cameroon. Patients were cases of confirmed venous thromboembolic disease (VTE). Results: A total of 78 case files were retained for this study, giving an in-hospital prevalence of 4.4 per 1000 admissions. There were 42 (53.8%) males and 36 (46.1%) females. Their ages ranged from 18 to 89 years (median: 53 years, [IQR: 40 - 61]). There were 37 (47.4%) cases of Deep Vein Thrombosis (DVT), 31 (39.7%) cases of Pulmonary Embolism (PE), and 10 (12.8%) cases of PE associated with DVT (12.8%). The main risk factors were obesity (44.9%), hypertension (37.2%), immobility (20.5%), and long - haul travel (17.9%). The most frequent clinical presentations in PE were dyspnea (80.5%) and chest pain (65.9%). There were 8 (10%) in - hospital deaths. Conclusion: About twelve cases of VTE are seen yearly at the DGH, with an in - hospital mortality of ten percent. Obesity and hypertension were the main risk factors, with dyspnea and chest pain being the main clinical manifestations in PE, and lower limb swelling the main symptom in DVT.
Venous thromboembolism (VTE) is a major cause of morbidity and mortality worldwide. It is also the most common complication in hospitalized patients in high income settings [
Data on the epidemiology of VTE are scarce in our setting. We carried out this cross-sectional descriptive study with the aim of reporting the epidemiology, main risk factors, clinical presentations and short term in-hospital outcome in patients with a diagnosis of VTE at the Douala General Hospital―Cameroon, a low-income setting in SSA.
Ethical statement: This study was approved by the institutional review board of the University of Douala, and the administration of the Douala General Hospital. This work was carried out in accordance with the Declarations of Helsinki. We report this work in accordance with the standards for reporting epidemiological studies (STROBE) guidelines.
Study Design and setting: We carried out a cross-sectional descriptive retrospective study at the Douala General Hospital (DGH). We recruited cases that were hospitalized in the internal medicine and the intensive care unit (ICU) of the hospital. The DGH is a tertiary health institution in Cameroon, central Africa sub-region. It serves as a teaching hospital of the University of Douala, and has a catchment population of about 3 million inhabitants. It is equipped with 2 ultrasound machines, and a 16 barrette multi-detector CT scan.
Participants: We reviewed the medical files of cases of VTE hospitalized in the hospital between January 2008 and April 2016 (6 years and 4 months). We included in the study confirmed cases of VTE disease. Confirmed cases had either contrast enhanced CT scan of the lungs, and or venous ultrasound performed after the primary diagnosis. Those with incomplete medical records (no confirmatory test done) were excluded.
Variables and measures: For each patient, we collected the following data: Socio-demography (age and sex), origin (home, other wards, and other hospitals), hospitalization ward (internal medicine, ICU), risk factors of VTE (medical, surgical, and social), clinical presentations (pulmonary embolism, deep vein thrombosis of the leg), electrocardiographic presentation, location of thrombus on vascular ultrasound (proximal, distal, or both), treatment (short and long term), and outcome (alive at discharge or death).
Sample size and Statistical analysis: This was a cross-sectional study. A convenient sample of all eligible cases seen during the study period was considered. We analyzed the data with the software IBM SPSS version 20. We have presented continuous variable (age) as median (interquartile range), and discrete variables as frequencies and percentages. A p value < 0.05 was considered significant for observed differences or associations.
Patients: During the period of the study, a total of 17703 patients were admitted in the internal medicine and ICU. Of these, 113 patient cases were identified as potential cases of VTE. We excluded 35 cases (4 missing files, 22 incomplete files, and 9 diagnoses were changed). A total of 78 case files (about 12 cases seen per year) were retained for this study. This gives an in-hospital prevalence of VTE of 4.4 cases per 1000 admissions (
Descriptive data:
Outcome data and main results:
swollen inferior limb in 42 (89.4%) cases. In order to confirm the diagnosis of PE, a pulmonary angiography was done in 38 (92.7%) cases. Endo-luminal defects were present in 36 (94.7%) cases. There was a parenchymal involvement in 27 (71.1%) cases, with 6 (15.8%) cases of pulmonary infarction, and 6 (15.8%) cases of pleural effusion. In all, 37 ECGs were performed with 29 (78.4%) being abnormal. The most frequent findings were sinus tachycardia in 19 (51.35%) cases, anterior T-wave inversion in 13 (35.14%) cases, and S1Q3 pattern in
Variables | Frequency (%) |
---|---|
Gender | |
Male | 42 (53.8) |
Female | 36 (46.2) |
Age Group | |
<35 | 12 (15.4) |
35 - 44 | 17 (21.8) |
45 - 54 | 13 (16.7) |
55 - 64 | 20 (25.6) |
65 - 74 | 11 (14.1) |
>75 | 5 (6.5) |
Origin | |
Home | 42 (53.8) |
Referred from other hospitals | 27 (34.6) |
Transferred from other wards | 9 (11.5) |
Hospitalisation Ward | |
Internal medicine | 74 (94.9) |
Intensive Care Unit | 4 (5.1) |
Variable | Frequency (%) |
---|---|
Medical risk factors | |
Hypertension | 29 (37.2) |
Previous VTE | 9 (11.5) |
Autoimmune disease | 1 (1.3) |
Cancer | 5 (11.5) |
Pulmonary tuberculosis | 3 (3.8) |
Cardiovascular disease | 10 (12.8) |
HIV infection | 11 (14.1) |
Dyslipidemia | 3 (3.8) |
Central venous catheterization | 4 (5.1) |
Others | 15 (19.2) |
Recent surgical intervention | |
Gynecology/obstetrical | 4 (5.1) |
Obstetrical | |
Pregnancy | 1 (1.3) |
Puerperium | 2 (2.6) |
Abortion | 1 (1.3) |
Social risk factors | |
Exogenous hormones | 1 (1.3) |
Immobility | 16 (20.5) |
Smoking/toxicomania | 8 (10.3) |
Obesity | 35 (44.9) |
Long-haul travel (≥4 hours) | 14 (17.9) |
Family history of VTE | 3 (3.8) |
Variables | Frequency (%) |
---|---|
Pulmonary Embolism (n = 41) | |
Dyspnea | 33 (80.5) |
Chest pain | 27 (65.9) |
Syncope | 4 (9.8) |
Heamoptysis | 3 (7.3) |
Respiratory distress | 7 (17.1) |
Shock | 2 (4.9) |
Right heart failure | 1 (2.4) |
Altered state of consciousness | 3 (7.3) |
Deep Vein Thrombosis (n = 47) | |
Calf stiffness | 21 (44.7) |
Homanns sign | 24 (51.1) |
Pain | 37 (78.7) |
Inferior limb swelling | 42 (89.4) |
Electrocardiogram (n = 37) | |
Right Ventricular hypertrophy | 1 (2.4) |
Incomplete right bundle branch block | 5 (12.2) |
S1Q3 pattern | 11 (26.8) |
Anterior T-wave inversion | 13 (31.7) |
Tachycardia | 19 (46.3) |
Echography of leg Veins (n = 47) | |
Proximal location only | 25 (53.2) |
External iliac vein | 2 (4.3) |
Femoral vein | 6 (12.8) |
Ilio-femoral vein | 5 (10.6) |
Popliteal vein | 8 (17) |
Ilio-femoro-popliteal vein | 1 (2.1) |
Popliteo-femoral vein | 18 (38.3) |
Distal location only | 4 (8.5) |
Sural vein | 17 (36.1) |
Peroneal vein | 2 (4.3) |
Posterior tibial vein | 1 (2.1) |
Both Distal and proximal locations | 16 (34) |
Venous Thrombo-Embolism Treatment (n = 78) | |
Low Melecular Weight Heparin | 73 (93.6) |
Vitamin K antagonists | 62 (79.5) |
Unfractioned heparin | 8 (10.3) |
New oral anticoagulants | 1 (1.3) |
Elastic compressive stockings | 15 (19.2) |
Patient education | 21 (26.9) |
11 cases (29.73%). DVT cases were all confirmed by compression ultrasounds performed on all 47 cases, which showed the locations of the thrombi. On establishment of a diagnosis, patients were placed on treatment. These treatments included unfractionated heparins, Low-Molecular-Weight Heparin (LMWH), and vitamin K antagonists. New oral anticoagulant was used in a one case. Thrombolysis and embolectomy were not used as means of treatment. The duration of hospitalization ranged from 1 to 36 days (median: 11days [IQR: 8 - 16]).
The objective of this cross-sectional descriptive study was to describe the epidemiology, clinical presentations, and outcome of VTE at the Douala General Hospital (DGH). VTE was seen in 4.4 cases per 1000 admissions in the internal medicine unit and ICU. About twelve cases of VTE are seen yearly at the DGH, with an in-hospital mortality of ten percent. Obesity and hypertension were the main risk factors, with dyspnea and chest pain being the main clinical manifestations in PE, and lower limb swelling the main symptom in DVT.
The male predominance this study is similar to the 55% reported by Kingue et al. in Yaoundé―Cameroon [
et al. [
The most frequent risk factors of a VTE in this study were morbid obesity (44.9%), hypertension (37.2%), immobility (20.5%), long-haul travel (17.9%) and HIV infection (14.1%). These results were partly similar to those obtained by Ogeng’o et al. who reported as main risk factors DVT, hypertension, pulmonary tuberculosis, HIV infection, puerperium, diabetes mellitus and cigarette smoking [
In this study, the most recurrent clinical presentation of a PE was a dyspnea and chest pain. This was similar to Igun et al. who reported severe dyspnea and central chest pain as main clinical presentation, associated to loss of consciousness, hemoptysis, and mental confusion [
The in-hospital mortality rate during a VTE was 10%. Sotunmbi et al., Husain et al., and Lee et al. [
The main limitation of this study is the retrospective collection of data. This led to many case files being excluded because of missing key data. The result is a reduction in the power of the study, and alterations in the true in-hospital prevalence of VTE, its risk factors, and the outcome rate. This also, did not permit us to the study the incidence of VTE, which can only be assessed in Cohort studies.
The objective of this cross-sectional descriptive study was to describe the epidemiology, clinical presentations, and outcome of VTE at the Douala General Hospital (DGH). VTE was seen in 4.4 cases per 1000 admissions in the internal medicine unit and ICU. About twelve cases of VTE are seen yearly at the DGH, with an in-hospital mortality of ten percent. Obesity and hypertension were the main risk factors, with dyspnea and chest pain being the main clinical manifestations in PE, and lower limb swelling the main symptom in DVT.
None to declare.
None.
Study conception: FK, BH, MSD, HL, and BHMN. Study design: FK, BH, AD, MSD, HL, BHMN. Data collection: FK, BH, AM, JFK, CK, MSD, MS, HN, AC, SM, YW, RH, AK. Data analysis and Interpretation: AM, AMJ, FK, HL, BH, AD, YW, and MSD. Drafting of the manuscript: FK, BH, AM, AMJ, JFK, CK, SM, HN, RH, AK. All the authors have read and approved of the final draft for publication.
We thank the nursing staff of the Internal Medicine and the Intensive Care Unit of the DGH for helping with retrieving the patient records.
Kamdem, F., Ngahane, B.H.M., Hamadou, B., Mongyui, A., Doualla, M.S., Jingi, A.M., Dzudie, A., Monkam, Y., Ngote, H., Mouliom, S., Kenmegne, C., Fenkeu, J.K., Hentchoya, R., Kana, A., Coulibaly, A. and Luma, H. (2018) Epidemiology, Clinical Presentations and In-Hospital Mortality of Venous Thromboembolism at the Douala General Hospital: A Cross-Sectional Study in Cameroon, Sub-Saharan Africa. World Journal of Cardiovascular Diseases, 8, 123-132. https://doi.org/10.4236/wjcd.2018.82012