TITLE:
Efficacy of piperzine citrate, stabilized with Aluminium-Magnesium Silicate, against Helignosomoides bakeri
AUTHORS:
Maduike C. O. Ezeibe, Chigozie D. Dire, George N. Anosa, Ogechukwu N. Chikelu, Obianuju N. Okoroafor, Okechi K. Okorie, Augustine A. Ngene, Idika K. Idika, Temitope M. Ogunniran, Ihuoma E. Ezeala
KEYWORDS:
Anthelminthic Resistance; Aluminium-Magnesium Silicate; Stabilization; Piperazine Citrate; Helignosomoides bakeri
JOURNAL NAME:
Health,
Vol.4 No.10,
November
1,
2012
ABSTRACT: To test effect of a synthetic Aluminium-Magnesium Silicate (AMS) on anthelmintic efficacy of piperazine citrate (PC), 35 mice were infected by dosing each, 0.15 ml Helignosomoides bakeri sample which contained 200 infective larvae, per os. Following comfirmation of establishment of infection by faecal floatation, they were assigned into seven groups of 5 each, and were treated with piperazine citrate, per os, at rates of 110 mg/kg (PC), 110 mg/kg (PC in AMS), 82.5 mg/kg (PC), 82.5 mg/kg (PC in AMS), 55 mg/kg (PC) and 55 mg/kg (PC in AMS) respectively. The seventh group served as untreated control. Mean Eggs Per Gramm of faeces (EPG) were 375 ± 32.27, 175 ± 14.43, 830 ± 1.04, 70 ± 12.25, 850 ± 293.06, 370 ± 58.54 and 2,200 ± 2.55 respectively. This showed EPG reduction rates of 83%, 92%, 62%, 97%, 61% and 83% among the respective treated groups.