TITLE:
Nasosinus Metastases from Breast Cancer: A Review of Two Cases
AUTHORS:
Papa Macoumba Gaye, Mouhamadou Bachir Ba, Fatimatou Néné Sarr, Fallou Niang, Maimouna Mané, Franck Chouamou Aurélien Chemega
KEYWORDS:
Cancer, Breast, Nasosinus Metastasis, Senegal
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.10 No.4,
August
17,
2021
ABSTRACT: Context: Breast cancer affects more than 2 million women a year worldwide.
Improved treatments have made it possible to increase survival rates with more and more patients having time to develop
secondary locations. Nasosinus metastases from this cancer are rare. Two
recently treated breast cancer patients developed metastases to the sphenoidal
and maxillary sinuses. These cases gave rise to an examination of the incidence
of this disease, its diagnosis, the therapeutic means envisaged and the fate of
these patients. Method: We report the diagnostic and therapeutic data of
two patients suffering from breast cancer and presenting metastases at the
nasosinus level, with a focus on the interest of radiotherapy in palliative
care. Results: The two patients aged 56 and 60 presented in the course
of their breast cancer secondary localizations in the sphenoidal and maxillary
sinus confirmed by endoscopy and histology. All the cases presented massive
lesions associated with other secondary bone locations in particular. After
local radiotherapy and systemic chemotherapy treatment, one patient died 5
months after her diagnosis and the other was alive 16 months later. Conclusion: Nasal and sinus metastases from breast cancer are rare and have a poor
prognosis as disseminated disease, they do not respond well to conventional
systemic therapies even if palliative radiotherapy allows local control.