TITLE:
β-HCG Level as a Predictive Marker of Pregnancy Progression or Retrogression
AUTHORS:
George Gborienemi Simeon, Marymar Ezejimofor, Newton Cleston Odumoson
KEYWORDS:
β-HCG, Predictive, Marker, Pregnancy, Progression, Retrogression
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.11 No.6,
June
15,
2021
ABSTRACT: An ordered sequence of biologic events is precursors of the birth of a
healthy baby. Hormonal interactions acting as a nexus between the fetus,
placenta and mother that controls the establishment and progression of
pregnancy and fetal development are very important. We examined the role of
Beta-Human Chorionic Gonadotropin (β-HCG)
as a predictive marker. Applying radioimmunoassay that utilizes anti-sera
generated from specific β-submit of
HCG we evaluated the serum β-HCG
level in 60 pregnant women in the three trimesters. Results showed that there
was consistent increase in concentration that drops gradually and maintained a
plateau only to drop from the 40th week of pregnancy. 3 subjects
(5%) that had a sudden sharp drop in β-HCG
level resulted in complications. Inclusion of β-HCG level screening and monitoring in pregnancy will raise
assurance of progress or retrogression in pregnancy. We provide data that can
be used as a reference range for β-HCG
using this method.