Ayazi, S., Hagen, J.A., Chan, L.S., DeMeester, S.R., Lin, M.W., Ayazi, A., Leers, J.M., Oezcelik, A., Banki, F., Lipham, J.C., DeMeester, T.R. and Crookes, P.F. (2009) Obesity and gastroesophageal reflux: Quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms. Journal of Gastrointestinal Surgery, 13, 1440-1447. http://dx.doi.org/10.1007/s11605-009-0930-7

has been cited by the following article:

• TITLE: Lack of correlation between obesity and gastroesophageal reflux disease (GERD) in a pediatric cohort

  AUTHORS: Simon S. Rabinowitz, Sridhar Goli, Jiliu Xu, Xuchen Zhang, Anthony Nicastri, Virginia Anderson, Dimitre G. Stefanov, Steven M. Schwarz

  KEYWORDS: Pediatric; GERD; Obesity; Endoscopy; Histopathology

  JOURNAL NAME: Open Journal of Pediatrics, Vol.3 No.4, November 27, 2013

  ABSTRACT: Objectives: Previous reports correlating obesity with gastroesophageal reflux disease (GERD) in children have yielded conflicting results. This study examined whether increasing BMI (body mass index) correlated with increasing grades of endoscopic and/or histopathologic GERD in a cohort of inner city children. Designs and Methods: 340 consecutive children (1 - 18 years) were classified as obese (BMI > 95%) for age and gender. Both endoscopic findings and esophageal histopathology were characterized by graded adult GERD scoring systems. Normal and abnormal grades were then stratified based on BMI. Results: In the study cohort (mean age 10.5 ± 4.7 yrs), 29% were obese (BMI > 95%) and 24% of the total cohort demonstrated endoscopic features of GERD. With increasing severity of endoscopic GERD (from normal to advanced), the percentage of obese patients at each grade did not increase (Grade 0 = 30%, Grade 1 = 26%, Grades 2 - 4 = 30%). Histopathologic findings consistent with GERD were noted in 21% of the total population studied. Again, the percentage of obese children in each diagnostic category (Grades 0 - 3) did not increase with increasing severity of inflammation. Conclusions: In this cohort of inner city children, obesity was not associated with an increased prevalence of GERD as defined by adult scoring systems.