Z. Shutenko, Y. Henry, E. Pinard, et al., “Influence of the Antioxidant Quercetin in Vivo on the Level of Nitric Oxide Determined by Electron Paramagnetic Resonance in Rat Brain during Global Ischemia and Reperfusion,” Biochemical Pharmacology, Vol. 57, No. 2, 1999, pp. 199-208. doi:10.1016/S0006-2952(98)00296-2

has been cited by the following article:

• TITLE: Assessment of Secondary Metabolites from Marine-Derived Fungi as Antioxidant

  AUTHORS: Nihad Abdel-Monem, Ahmed M. Abdel-Azeem, E. S. H. El Ashry, Doaa A. Ghareeb, Asmaa Nabil-Adam

  KEYWORDS: DPPH; TBARS; Marine Drugs; Marine Derived Fungi; Anti-Inflammatory; Antioxidant Capacity

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.3 No.3, September 20, 2013

  ABSTRACT: Marine derived fungi are considered as a promising source of novel drugs due to their biodiversity and consequent chemo-diversity. Although marine microorganisms especially fungi are not well defined taxonomically, making this a promising frontier for the discovery of new medicines. This study focused on marine derived fungi as a model for bioactive exploration for new entities with anti-inflammatory and antioxidant capacity. Three in-vitro assays were used to investigate the bioactive antioxidant potentiality of fungal extracts. Thiobarbituric acid (TBARS),α,α-Diphenyl-β- picrylhydrazyl (DPPH) and NO assay are based on their total phenolic and flavonoid content of each extract group. Ch. globosum recorded the highest antioxidant activity (92.82%) in TBARS assay, while G. dankaliensis came first by recording 59.28% in DPPH assay in comparison with ascorbic acid (61.83%). In NO inhibition assay, N. oryzae showed 49.3% comparing with ascorbic acid (73.12%). From the preliminary result of our extracts, we can consider the marine derived fungi extracts as promising antioxidant and anti-inflammatory drug candidate.