TITLE:
Insulin-Like Growth Factor-1 and Osteocalcin Are Correlated with Markers of Osteoporosis in Postmenopausal Women with Type-2 Diabetes
AUTHORS:
Maher A. Kamel, Madiha H. Helmy, Anna N. Abou Rayah, Nevine Mohannad, Huda M. N. Hania
KEYWORDS:
Osteoporosis; Type 2 Diabetes; Postmenopause; IGF-1; Osetocalcin; OPG; RANK
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.3 No.5,
August
30,
2013
ABSTRACT:
Objective: The study was conducted to evaluate the relation between insulin-like growth
factor-1 and osteocalcin and markers of bone modulation (osteoprotegerin; OPG,
receptor activator nuclear kappa B; RANK and RANK ligand; RANKL) in postmenopausal
Type 2 diabetic women with and without osteoporosis. Methods: The study
was conducted on 90 female divided into three groups (30 each). Group I included healthy
postmenopausal women as a control, Group II included diabetic
postmenopausal women without osteoporosis Group III included diabetic postmenopausal women with osteoporosis. Fasting blood samples were
obtained for the determination of blood glucose, HbA1c, total and ionized
calcium, OPG, RANK and RANKL. Also the levels of IGF-1 and osteocalcin were
assessed. Results: In postmenopausal Type 2 diabetic women, the
osteoporosis resulted in derangement in OPG/sRANKL system. The serum level of
OPG was elevated while sRANKL declines in osteoporotic
postmenopausal Type 2 diabetic women. IGF-1 level decreased in diabetic
postmenopausal women but those women with osteoporosis showed a
great decline by about 60%. IGF-1 level in osteoporotic diabetic postmenopausal
women was correlated with BMD and most bone turnover markers (OPG, sRANKL,
OPG/sRANKL). Osteocalcin declined significantly only in those women with
osteoporosis not without osteoporosis. Conclusions: The circulating
levels of OPG and sRANKL were not useful markers for bone status in
postmenopausal women while the circulating levels of IGF-1 and osteocalcin might give
useful information about bone status in postmenopausal diabetic women.