TITLE:
The Effects of Aqueous Extracts of Acalypha wilkesiana Supplementation and Exercise Training on Hematopoietic System in Rats
AUTHORS:
Alfred F. Ehiaghe, Joy I. Ehiaghe, Igere E. Bright, Iyen I. Roland
KEYWORDS:
Acalypha Wilkesian; Serum IgG; ELISA; CD4 Cells; CD8 Cells; Exercise
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.4 No.9,
August
29,
2013
ABSTRACT:
The aim of
this study is to compare the effects of single and combined oral administration
of fresh aqueous extracts of Acalypha
wilkesiana supplementation at 300 mg/ml and exercise training on some
immuno indicator parameters in Rats. The study was carried out in the College
of Health Sciences, Department of Hematology, Igbinedion University, Okada
between the Month of June and July, 2012. Following 30 days post-oral
administration of extracts on (Group 2 and Group 3), exercise training on
(Group 2 and Group 4) and No treated on Group 1, hematological parameters
were determined using the sysmex®Automated Hematological Analyzer,
while CD4 and CD8 cells were estimated using Partec cyflow counter and serum
IgG is determined using the ELISA Method. CD4 cells, CD8, and Total WBC
count show a statistically significant increase while Hb concentration and IgG
level show a statistically significant decrease in Group 2 and Group 4 (P 0.05), Table 2. Acalypha
wilkesiana at a concentration of 300 mg/g/day seems to be
immuno-protective in Rats. Single or combine effects of prolonged exercise and A. wilkesiana produce significant change in some immuno indicators parameters. However,
the molecular mechanism behind their combined effect would require further
investigation.