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has been cited by the following article:

• TITLE: Synthesis and bioevaluation of novel heterostilbenes as potential anti-inflammatory and anti-angiogenic agents

  AUTHORS: Chien-Ming Huang, An-Rong Lee, Jiajiu Shaw, Wen-Hsin Huang

  KEYWORDS: Resveratrol Analogs; Benzothiazolium; Anti-Angiogenesis; Carrageenan-Induced Edema

  JOURNAL NAME: Modern Research in Inflammation, Vol.2 No.3, July 17, 2013

  ABSTRACT: Novel heterocyclic analogs of resveratrol, (E)-stilbene analogs, were readily prepared by conjugation of a heterocyclic benzothiazolium moiety with the core styrene structure of resveratrol and evaluated for their biological properties. The results showed that these analogs were superior to resveratrol in 1) anti-angiogenesis in vitro, 2) nitric oxide inhibition in vitro, and 3) inhibition of carrageenan-induced edema in vivo. In summary, introduction of a heterocyclic benzothiazolium moiety to replace one of two aromatic rings from the core stilbene structure of resveratrol provided beneficial biological properties and is worthy of further investigation.