TITLE:
Analysis of clinical symptoms and signs in cases of oral submucous fibrosis which have transformed into squamous cell carcinoma
AUTHORS:
Xinchun Jian, Xieshan Huang, Deyu Liu, Pu Xu, Xiacheng Liu
KEYWORDS:
Oral Cancer; Oral Submucous Fibrosis; Oral Leukoplakia; Oral Linchen Planus; Oral Precancerous Lesion
JOURNAL NAME:
Open Journal of Stomatology,
Vol.3 No.3,
June
27,
2013
ABSTRACT:
To analyze the clinical symptoms and signs in cases of
oral submucous fibrosis which has transformed into squamous cell carcinoma, twenty-nine
patients with squamous cell carcinoma correlated with oral submucous fibrosis,
leukoplakia, lichen planus were taken biopsy for positive diagnosis. The
clinical and pathological diagnosis of oral submucous fibrosis depended on
clinical and pathological diagnostic standards. The oral submucous fibrosis
involving different portions and size in the mouth was observed and recorded.
The portions of oral cancer, clinical findings and symptoms, cancerous size,
the conditions of the local lymphatic nodes and of oral submucous fibrosis
correlated with squamous cell carcinoma in the mouth, oral leukoplakia, lichen planus were also observed
and recorded. In twenty-nine patients with oral squamous cell carcinoma,
duration from oral submucous fibrosis transformed into oral cancer ranged
from 2 to 15 years with an average year of 6.69. The serious degrees of oral
submucous fibrosis in the patients with oral cancer were that the moderately
advanced stage was found in 3 cases (10.34%) and the advanced stage was found
in 26 cases (89.65%). The cancerous portion was that the buccal mucosa was
found in 9 cases (31.03%); the tongue was found in 14 cases (48.27%); the other
portion was found in the rest 6 cases (20.68%). Among the twenty-nine patients
twenty-three patients with squamous cell carcinoma were associated with leukoplakia
(79.31%), five patients were associated with lichen planus (17.24%). Twenty-seven
patients (93.1%) had habits of betel quid chewing, smoked cigarette and drank
alcohol, the rest two patients had habits of betel quid chewing and cigarette
smoking. The present study demonstrates that oral submucous fibrosis is a real
precancerous lesion and may transform into squamous cell carcinoma in the
mouth.