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B. Van Calster, I. VandenBempt, M. Drijkoningen, N. Pochet, J. Cheng, S. Van Huffel, W. Hendrickx, J. Decock, H. J. Huang, K. Leunen, F. Amant, P. Berteloot, R. Paridaens, H. Wildiers, E. Van Limbergen, C. Weltens, D. Timmerman, T. Van Gorp, A. Smeets, W. Van den Bogaert, I. Vergote, M. R. Christiaens and P. Neven, “Axillary Lymph Node Status of Operable Breast Cancers by Combined Steroid Receptor and HER-2 Status: Triple Positive Tumours Are More Likely Lymph Node Positive,” Breast Cancer Research and Treatment, Vol. 113, No. 1, 2009, pp. 181-187. doi:10.1007/s10549-008-9914-7
has been cited by the following article:
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TITLE:
The Association between Sentinel Lymph Node Metastasis and Ki-67 Labeling Index
AUTHORS:
Yu Koyama, Hiroshi Ichikawa, Jun Sakata, Eiko Sakata, Kumiko Tatsuda, Miki Hasegawa, Chie Toshikawa, Naoko Manba, Mayuko Ikarashi, Toshifumi Wakai
KEYWORDS:
Breast Cancer; Sentinel Lymph Node; Molecular Subtypes; Ki-67 Labeling Index
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.2 No.3,
June
24,
2013
ABSTRACT:
Background: The purpose of this study was to elucidate the
association between sentinel lymph node (SLN) metastasis and Ki67 labeling
index and to elucidate whether Ki-67 was useful or not for prediction of SLN
metastasis in breast cancer. Methods: We identified 343 invasive breast cancer
patients with sentinel lymph node biopsy (SLNB) from 2003 to 2012. The
association between SLN status and clinicopathological features, molecular
subtypes and Ki-67 labeling index were evaluated. Results: SLN metastasis was
detected in 79 patients (23.0%). SLN metastasis was significantly associated
with clinical T-stage (p = 0.0003), lymphovascular involvement (LVI) (p 0.0001).
Ki-67 labeling index of primary tumor was significantly lower in SLN positive
patients (p = 0.0331), and Ki-67 cut-off point of 7.5% was useful for
dividing SLN positive from negative (p = 0.0197). Conclusion: Low value of
Ki-67 labeling index, in addition to progression of clinical T-stage and
presence of LVI, is significantly associated with SLN metastasis, and it seems
to be useful to consider Ki-67 labeling index for SLN metastasis prediction.
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