TITLE:
Evaluation of the Efficacy and Safety for Atopic Dry Skin of a Medicinal Moisturizing Lotion (Mentholatum AP Soft Medicinal Moisture Lotion) Prepared by a High-Pressure Emulsification Method
AUTHORS:
Tokuya Omi, Yuriko Ochiai
KEYWORDS:
Atopic Dermatitis; Nanoparticle; TEWL; Vaseline; Moisturizer
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.3 No.2,
June
13,
2013
ABSTRACT:
In order to evaluate the efficacy and
safety of Mentholatumò AP Soft Lotion (APA), which is a
Vaseline-based preparation that has been converted to nanoparticles by
high-pressure emulsification technology, we conducted a study of 4-week
continuous use on the atopic dry skin of patients with minor to moderate atopic
dermatitis (AD). The results showed that improvements in the skin findings
(dryness and scaling) and itching were observed beginning one week after
starting to apply APA and that the symptoms had almost completely resolved at 3
to 4 weeks after the start of application. In addition, a significant increase
in the degree of high-frequency conductivity, which is an indicator of the
amount of moisture in the stratum corneum, and significant decrease in
transepidermal water loss (TEWL) were observed, and improvements in skin
functions were observed. The results
for overall degree of improvement showed “improvement” or better in 100% of the
subjects, and no side effects were observed in any of the cases. Based on the
above results, it was concluded that APA is a preparation that has excellent
efficacy and safety as skin care for atopic dry skin, in which reduced stratum
corneum function is observed in the skin, and as a supplemental method of
treatment of AD or treatment method to maintain remissions.