TITLE:
Interferon-induced progression of autoimmune thyroiditis with enlarged thyroid glands in gynecological patient: A case report and literature review
AUTHORS:
Ospan Mynbaev, Marina Eliseeva, Artem Chernov, Ioannis Kosmas, Andrea Tinelli, Victor Radzinsky, Victor Tsarev
KEYWORDS:
Autoimmune Thyroiditis; Human Papillomavirus; Interferon; Thyroid Glands
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.3 No.2,
March
13,
2013
ABSTRACT:
A case report presents a progression of autoimmune thyroiditis with an abnormal enlargement of the thyroid glands and increased thyreotropin hormone concentration-associated with interferon treatment in human papillomavirus infected patient with the autoimmune thyroiditis and a daily L-thyroxin hormone replacement therapy background. Observation was supplemented with a brief review of literature and discussion. On the basis of this observation and a brief review of literature authors suggested that the potential adverse effects of interferon therapy are overbalanced than its benefits for gynecological patients, therefore any interferon treatment should be recommended with strict indications as well as after screening of conditions and functions of thyroid glands and other interferon target organs to avoid interferon treatment side effects. Practitioners especially gynecologists should inform their patients about pleiotropic interferon effects and its high frequent and wide range side effects before to start such kind of treatment.