TITLE:
Efficacy and Safety of Nasal Administration of “Na-no-L-DOPA” Based on PLGA Nanoparticles
AUTHORS:
I.G. Kondrasheva, T.A. Antipova, G.G. Barsegyan, P.Ye. Gambaryan, A.A. Guseva, A.A. Kamensky
KEYWORDS:
Nanopaticls; L-DOPA; Nasal Administration; Parkinson’s Disease
JOURNAL NAME:
Engineering,
Vol.4 No.10B,
January
16,
2013
ABSTRACT:
Inclusion of L-DOPA,
the standard Parkinson’s disease medication, into polymeric particles (PLGA)
results in optimization the drug metabolism and increasing its bioavailability,
significantly increases of physical endurance, better coordination and lower
anxiety in Wistar rats, when chronically administered nasally.