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has been cited by the following article:

• TITLE: Preparation and characterization of genipin-cross-linked chitosan microparticles by water-in-oil emulsion solvent diffusion method

  AUTHORS: Jesada Karnchanajindanun, Mangkorn Srisa-ard, Prasong Srihanam, Yodthong Baimark

  KEYWORDS: Chitosan microparticles; Porous structure; Genipin; Cross-linking; Morphology

  JOURNAL NAME: Natural Science, Vol.2 No.10, October 29, 2010

  ABSTRACT: Chitosan (CS) microparticles with and without cross-linking were prepared by a water-in-oil emulsion solvent diffusion method without any surfactants. Aqueous CS solution and ethyl ace- tate were used as water and oil phases, respectively. Genipin was used as a cross-linker. Influ- ences of genipin ratios and cross-linking times on CS microparticle characteristics were investigated. Non-cross-linked and cross-linked CS microparticles were spherical in shape and rough in surface. Microparticle matrices showed porous structures. Surface roughness, mean par- ticle sizes and bulk density of CS microparticles increased and their dissolutions in acetic acid solution decreased when genipin ratio and cross- linking time increased.