TITLE:
KF-Al2O3 as an Efficient and Recyclable Basic Catalyst for the Synthesis of 4H-Pyran-3-carboxylates and 5-Acetyl-4H-pyrans
AUTHORS:
Iadeishisha Kharbangar, Md. Rumum Rohman, Hormi Mecadon, Bekington Myrboh
KEYWORDS:
4H-Pyran derivatives; Ethanol; KF-Al2O3; Room Temperature; Three-Component
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.2 No.3,
September
28,
2012
ABSTRACT: KF-Al2O3 as a recyclable basic catalyst for the three-component synthesis of 4H-pyran derivatives by the reaction of aldehydes, malononitrile and active methylene dicarbonyl compounds in ethanol at room temperature is described. The protocol is environmentally benign and offers rapid access to a wide array of 4H-pyran heterocycles in good to excellent yields.