H. Y. Leung, P. Y. Chiu, M. K. T. Poon and K. M. Ko, “A Yang-Invigorating Chinese Herbal Formula Enhances Mitochondrial Functional Ability and Antioxidant Capacity in Various Tissues of Male and Female Rats,” Rejuvenation Research, Vol. 8, No. 4, 2005, pp. 238-247. doi:10.1089/rej.2005.8.238

has been cited by the following article:

• TITLE: “Qi-Invigorating” Chinese Tonic Herbs (Shens) Stimulate Mitochondrial ATP Generation Capacity in H9c2 Cardiomyocytes in Situ and Rat Hearts ex Vivo

  AUTHORS: Hoi Shan Wong, Weng Fat Cheung, Wai Ling Tang, Kam Ming Ko

  KEYWORDS: Qi; Chinese Medicine; ATP; Mitochondria; Cardiomyocytes

  JOURNAL NAME: Chinese Medicine, Vol.3 No.2, March 29, 2012

  ABSTRACT: In the study, using ethanol extracts of Renshen (Panax ginseng C A Meyer), Xiyangshen (Panax quinquefolius L.) and Dangshen (Codonopsis pilosulae), we investigated the effect of these “Qi-invigorating” Chinese tonic herbs on mitochondrial ATP generation capacity (ATP-GC) in H9c2 cardiomyocytes in situ and rat hearts ex vivo. All three types of “Shens” stimulated mitochondrial ATP-GC, with Renshen being most potent. While a parallel enhancement in mitochondrial ATP-GC was observed in Renshen- and Xiyangshen-pretreated rats, Dangshen treatment did not produce detectable effect ex vivo. The discrepancy between in situ and ex vivo assays for Dangshen may be attributed by its limited oral-bioavailability to the heart. The tissue specific activity of Shens on mitochondrial ATP-GC may be explained by the “Meridian Theory” in traditional Chinese medicine.