G. D. Rose, P. J. Fleming, J. R. Banavar and A. Maritan, “A Backbone Based Theory of Protein Folding,” Proceedings of the National Academy of Science, Vol. 103, No. 45, 2006, pp. 16623-16333. doi:10.1073/pnas.0606843103

has been cited by the following article:

• TITLE: Levinthal’s Paradox Revisited, and Dismissed

  AUTHORS: Arieh Ben-Naim

  KEYWORDS: Protein Folding; Levinthal Paradox; Hydrophilic Forces; Markov Process

  JOURNAL NAME: Open Journal of Biophysics, Vol.2 No.2, April 27, 2012

  ABSTRACT: This article is concerned with the so-called Levinthal’s paradox. It will be argued that many have sought a “solution” to Levinthal’s paradox, where in fact, the “solution” already appeared in Levinthal’s original articles. Most of the subsequent suggested “solutions” were inadequate solutions to a non-paradox. It is shown that the discovery of strong hydrophilic forces not only dismisses the Levintal paradox, but also provides a solution to the general problem of protein folding. A simple model based on the Markov process is presented to demonstrate how a strong biased-force can dramatically reduce the number of steps required to reach the stable native 3-D structure of the protein.