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https://doi.org/10.1038/s41598-017-07420-4

has been cited by the following article:

• TITLE: Essential Oils as an Alternative to Antibiotics to Reduce the Incidence and Severity of Necrotic Enteritis in Broiler Chickens: A Short Review

  AUTHORS: Makenly E. Coles, Brittany D. Graham, Juan D. Latorre, Victor M. Petrone-Garcia, Xochitl Hernandez-Velasco, Inkar Castellanos-Huerta, Xiaolun Sun, Billy M. Hargis, Saeed El-Ashram, Awad A. Shehata, Guillermo Tellez-Isaias

  KEYWORDS: Necrotic Enteritis, Essential Oils, Chickens, Clostridium perfringens, Alternatives to Antibiotics

  JOURNAL NAME: Food and Nutrition Sciences, Vol.14 No.3, March 27, 2023

  ABSTRACT: Due to the removal of antibiotic growth promoters (AGPs) and consumer pressure for antibiotic-free (ABF) or no antibiotics ever (NAE) poultry production, there is a need for sustainable alternatives to prevent disease in commercial poultry operations. Without AGPs, there has been a rise in diseases that were traditionally controlled by subtherapeutic levels of antibiotics in the diet. This has impacted the health of commercial poultry and has been a significant cost to poultry producers. To mitigate this, the industry has started to investigate alternatives to antibiotics to treat these forthcoming health issues, such as necrotic enteritis (NE). NE is an enteric disease caused by an over proliferation of toxigenic Clostridium perfringens (CP) in the gastrointestinal tract. Although CP is a commensal in the avian intestinal tract, dysbiosis caused by inflammation and impaired intestinal integrity facilitates uncontrolled replication of CP. Infectious agents, such as Eimeria maxima, appear to be a predominant predisposing factor that promotes NE. However, non-infectious stressors, including dietary changes, have also been associated with NE to some degree. As a result of increased pressure to restrict the use of antibiotics, there is a need for research evaluating the efficacy of alternatives, such as plant-derived essential oils, as potential tools to mitigate NE in commercial poultry flocks. The aim of this study is to review the effects of essential oils as an alternative to antibiotics to reduce the incidence and severity of necrotic enteritis in broiler chickens.