TITLE:
Clinical Features of Giant Cell Tumor of Bone in Elderly Patients
AUTHORS:
Hiroyuki Tsuchie, Makoto Emori, Hiroyuki Nagasawa, Yasutaka Murahashi, Emi Mizushima, Junya Shimizu, Toshihiko Yamashita, Naohisa Miyakoshi
KEYWORDS:
Giant Cell Tumor, Bone, Elderly, Local Recurrence
JOURNAL NAME:
Open Journal of Orthopedics,
Vol.11 No.9,
September
17,
2021
ABSTRACT: Background: Giant cell tumor of the bone (GCTB)
occurs most often in younger individuals aged between 20 and 40 years. However,
it also occurs in a small proportion of elderly people. Therefore, it is
necessary to determine the clinical characteristics of GCTB in elderly people,
as only few reports have completely examined the characteristics of GCTB in
elderly patients. Methods: This retrospective study enrolled 69 patients with
benign GCTB. Patients’ information on age, sex, anatomical location and size,
Campanacci grade, pathological fracture, treatment for primary tumors, local
and distant relapse, and outcome was collected. We compared these clinical
courses between the younger and older groups. We divided the age groups into
three subgroups: ≤54 years and ≥55 years, ≤59 years and ≥60 years, and ≤64
years and ≥65 years. We compared the two groups in each subgroup. In addition,
we examined factors affecting local recurrence and distant metastasis. Results:
Tumor size was significantly larger in
the older group between the two subgroups of 55 and 60 years. Kaplan-Meier
curves for local recurrence-free survival and distant metastasis-free survival
between the two subgroups of 65 years showed significant differences (p = 0.0183 and p = 0.0014). In the multivariate logistic
regression analyses, female sex, curettage-only surgical procedure, and
denosumab usage before surgery affected local recurrence. Conclusion: Age is unlikely to affect local recurrence and distant
metastases in GCTB patients, but local recurrence and distant metastases may be
noted in elderly patients aged ≥65 years with GCTB.