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https://doi.org/10.1038/ng.2735

has been cited by the following article:

• TITLE: Polymorphisms of the Toll-Like Receptor-2 Gene in Patients with Leprosy and Their Healthy Contacts

  AUTHORS: Luana Nepomuceno Gondim Costa Lima, Letícia Siqueira Moura, Jasna Leticia Pinto Paz, Maria do Perpétuo Socorro Amador Silvestre, Daniele Melo Sardinha, Letícia Diogo de Oliveira Moura, Karla Valéria Batista Lima

  KEYWORDS: Polymorphism, Toll-Like Receptors, Leprosy

  JOURNAL NAME: Open Journal of Immunology, Vol.10 No.3, August 18, 2020

  ABSTRACT: Leprosy is an immunopathology caused by M. leprae; its evolution depends on immunological and genetic aspects of the host. The objective was verifying the relationship between SNPs 2029 and 2258 of the TLR-2 gene and leprosy. Blood samples from 127 individuals were analyzed: 45 patients, being 34 multibacillary (MB) and 11 paucibacillary (PB) and 82 contacts, in the municipalities of the State of Pará-Brazil. SNPs 2029 and 2258 of the TLR-2 gene were genotyped by sequencing on the ABI 3130 Genetic Analyzer (Applied Biosystems), analyzed using Fisher’s exact test. Distribution of SNP 2029 genotypes: all MB individuals presented the C/C genotype and the mutant (C/T) genotype was observed in contacts and PB. Alleles: all MB individuals presented only C allele and the mutant allele (T) was observed in contacts and PB. SNP 2258 genotypes: 79 contacts had G/G genotype and only 3 had G/A genotype, the MB group had only G/G genotype and the PB group was predominant G/G, with only 1 G/A genotype. Alleles: all MB individuals had allele G and the mutant allele (A) was observed in contacts and PB. The association between the SNPs and the susceptibility or protection to leprosy was not observed.