Liu, Z., Long, W., Tu, M., Chen, S., Huang, Y., Wang, S., et al. (2020) Lymphocyte Subset (CD4+, CD8+) Counts Reflect the Severity of Infection and Predict the Clinical Outcomes in Patients with COVID-19. Journal of Infection.
https://doi.org/10.1016/j.jinf.2020.03.054

has been cited by the following article:

• TITLE: COVID-19: Lymphocyte Subpopulations Monitoring in Critically Ill Patients

  AUTHORS: Amra Ziadi, Abdelhamid Hachimi, Raja Hazime, Imane Brahim, Brahim Admou, Fouzia Douirek, Ahmed R. El Adib, Said Younous, Abdenasser M. Samkaoui

  KEYWORDS: SARS-CoV-2, Coronavirus Disease 2019, Lymphocyte Subsets, Critical Care Outcomes

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.11 No.8, August 7, 2020

  ABSTRACT: Background: The alteration of lymphocyte subpopulations can help to predict the severity and the prognosis of severe Coronavirus disease 2019 (COVID-19). Our goal was to describe the kinetics of lymphocyte subsets, and their impact on the severity and mortality in critically ill COVID-19 patients. Methods: We collected demographic data, comorbidities, clinical signs on admission, laboratory findings on admission then a follow-up during hospitalization. Lymphocyte subsets including CD3+ T cells, CD4+ T cells, CD8+ T cells, B cells, and natural killer (NK) cells were counted by flow cytometer. Results: On admission, we observed lymphopenia in 57% of cases, decreased CD3+ T cells in 76% of cases, decreased CD4+ T cells in 81% of cases, decreased CD8+ T cells in 62% of cases, decreased B cells in 52% of cases, and decreased natural killer (NK) cells in 33% of cases. After treatment, decreased CD3+ T cells, decreased CD4+ T cells, decreased CD8+ T cells, and decreased natural killer cells were predictor factors of mortality, in the univariable analysis. Conclusion: CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were predictor factors of severity, ICU mortality, and also a useful tool for predicting disease progression.