TITLE:
Digestive Pathologies during Chronic Renal Failure in the Nephrology and Haemodialysis Department at the University Hospital Center of Point G in Mali
AUTHORS:
Magara Samaké, Seydou Sy, Hamadoun Yattara, Moctar Coulibaly, Mamadou Badou Sanogo, Aboubacar Sidiki Fofana, Aboudou Messoum Dolo, Djénéba Maiga, Djénéba Diallo, Atabieme Kodio, Bakary Diarra, Karamoko Djiguiba, Djibril Sy, Saharé Fongoro
KEYWORDS:
Chronic Renal Failure, Digestive Signs, Mali
JOURNAL NAME:
Open Journal of Clinical Diagnostics,
Vol.10 No.1,
February
14,
2020
ABSTRACT:
Introduction: Chronic kidney disease (CKD) is the progressive and
irreversible loss of kidney function. It exposes to many complications, among
which, digestive complications. In Mali, we do not have data on the prevalence
of digestive pathologies in people with chronic renal failure, hence the
interest of this study. Objective: To determine the prevalence of
digestive pathologies and to describe their
manifestations during chronic renal failure. Patients and Methods: This was a
prospective cross-sectional study conducted from September 2016 to August 2017,
a period of 12 months. Included were patients hospitalized in our department
with CKD who received digestive endoscopy and/or liver serology. Results: Seventy-one patients underwent digestive endoscopy with oesogastroduodenal fibroscopy (60 patients),
rectoscopy (6 patients) and anoscopy (5 patients), i.e. 15.9% of those hospitalized. The mean age of the patients was
48 ± 14
years with extremes of 15 and 84 years. The sample consisted of 59.2% men
versus 40.8% women, for a sex ratio of 1.5. The functional signs are in order
of frequency: vomiting (72.4%), anorexia (51.3%) and epigastralgia (48.7%).
Terminal CKD by creatinine clearance accounted for 88.2% of cases, of which
47.4% were monitored by hemodialysis. Hepatitis
C virus infection was present in 21.3% of cases, hepatitis B (18%) and HIV
(7.5%). Endoscopic examinations were represented by fibroscopy (84.5%),
rectoscopy (8.5%) and anuscopy (7%). The fibroscopic lesions were respectively
gastric (96.8%), duodenal (14.1%) and esophageal (12.5%). They were dominated
by gastritis (40.5%), duodeno-gastric reflux (16.4%), pyloric gap (12.6%).
Rectoscopy found 4 cases of hemorrhoids, 2 cases of rectitis and no lesions
were observed at anuscopy. Conclusion: The prevalence of these digestive
manifestations and the endoscopic lesions encountered indicate the importance
of digestive endoscopy and the performance of hepatic serologies in chronic
renal failure patients with digestive symptoms and/or treated by hemodialysis.