TITLE:
Cholesterol or Fat Rich Diets Accelerate Natural Age-Decline on Adult Hippocampal Neurogenesis and Have an Impact in Memory and Like-Anxiety Behavior
AUTHORS:
Perla Leal-Galicia, María Carmen Sánchez-Torres, Marco Antonio Meraz-Ríos
KEYWORDS:
High-Fat Diet, High-Cholesterol Diet, Adult Hippocampal Neurogenesis, Memory, Like-Anxiety Behavior
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.10 No.10,
October
24,
2019
ABSTRACT: Diet is an
important health factor and it has been recently associated with
neurodegenerative diseases and cognitive decline. Here it was investigated the
effect of fatty acid or cholesterol rich diets with the possible acceleration
of the biological decline in adult hippocampal neurogenesis associated with
aging in middle-age rats, and its impact on anxiety and memory function. It was
found that a diet of 10 weeks with saturated fatty acids and cholesterol has a
detrimental effect on memory function, exerts like-anxiety behavior and
diminishes the presence of new generated neurons in the hippocampus in six
months old rats.