TITLE:
Efficient Cross-Coupling Reaction of Aryltrifluoroborates and Aroyl Chlorides for the Synthesis of Fluorine Substituted Aromatic Ketones
AUTHORS:
Mohammed Al-Masum, Tasfia Islam, Grady Clopton
KEYWORDS:
ArBF3K, Aroyl Chlorides, Direct Aroylation to Ketones, Minute Reaction
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.9 No.1,
March
18,
2019
ABSTRACT: The direct aroylation of ArCOPdCl with potassium aryltrifluoroborates establishes a new cross-coupling synthetic tool for the synthesis of various fluorine substituted benzophenones. The new microwave irradiated process is very efficient and produce high yield benzophenone products within minutes.