TITLE:
Diuretic Effect of Cymbopogon jwarancusa after Single and Multiple Doses in Rats
AUTHORS:
Sarah Jameel Khan, Syeda Afroz, Rafeeq Alam Khan
KEYWORDS:
Cymbopogon jwarancusa, Diuretic, Dimethyl Sulfoxide, Lipchitz Value, Furosemide
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.9 No.7,
July
20,
2018
ABSTRACT: Diuretics are
efficaciously used in management of various clinical emergencies like hypertension,
heart failure, cirrhosis, hypercalciuria, hematuria and nephrotic syndrome. Cymbopogon jwarancusa is an aromatic
perennial grass used in both traditional and Unani system of medicine to
eradicate diseases like colds, seasonal fever, asthma, tuberculosis, rheumatic
pain, back pain, toothache and nervous disorders. C. jwarancusa essential oils are used in perfumery, soap,
detergents, medicines and pharmaceutical industry. Monoterpenes and
sesquiterpenes constitute the highest composition in essential oil of C. jwarancusa. The present was designed
to compare the diuretic activity of C.
jwarancusa after single and multi-doses. Furosemide (20 mg/kg) was used as
reference drug and 10% DMSO was used as vehicle. Diuretic activity was noticed
by measuring urine volume and calculating diuretic and Lipchitz values. Maximum
diuretic response was observed at 500 mg/kg of extract after both single and
multi-dose administration. On basis of results it may be concluded that C. jwarancusa may be used as diuretic agent.