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Article citations


Janecek, J.K., Swanson, S.J., Sabsevitz, D.S., Hammeke, T.A., Raghavan, M., Rozman, M., et al. (2013) Language Lateralization by fMRI and Wada Testing in 229 Patients with Epilepsy: Rates and Predictors of Discordance. Epilepsia, 54, 314-322.

has been cited by the following article:

  • TITLE: Localizing the Language Network with fMRI and Functional Connectivity: Implications for Pre-Surgical Planning

    AUTHORS: Victoria Lyn Ives-Deliperi, James Thomas Butler

    KEYWORDS: Brain Mapping, fMRI, Functional Connectivity, Language, Pre-Surgical Planning

    JOURNAL NAME: Open Journal of Modern Neurosurgery, Vol.8 No.2, April 11, 2018

    ABSTRACT: Object: Functional MRI is frequently applied to lateralize language in pre-surgical planning, with potential to localize functionally important cortex too. Here we present BOLD signal activation maps and related functional connectivity, in response to three commonly administered fMRI language tasks. Methods: Datasets from 55 pre-surgical fMRI studies were analyzed. Verbal response naming, covert word generation and passive listening tasks were administered in all studies. Single-subject analyses, group analyses and region-of-interest analyses were conducted, and a multi-subject functional connectivity analysis was performed. Results: Single-subject analyses revealed that clinically important language regions were activated in all but three patients using the panel of tasks. Group analyses revealed significant bilateral BOLD signal increases in anterior and posterior language regions in response to verbal response naming and bilateral signal increase in posterior language regions only in response to passive listening. Covert word generation activated anterior language regions bilaterally and posterior language cortex in the dominant hemisphere. Functional connectivity analyses confirmed that activated regions were significantly correlated in all tasks. Conclusion: The findings of single-subject and group analyses add to the evidence supporting the use of a panel of fMRI tasks to map the language network for pre-surgical planning. Our findings support the additional use of functional connectivity analysis in routine language mapping to add to the localization value to fMRI. In addition, the results of our investigation demonstrate these three commonly applied tasks reliably activate unique aspects of the language network, which advocates closer individual inspection, guided by the surgical intervention planned.