TITLE:
Hashimoto Encephalopathy: Impact of Concussion
AUTHORS:
David S. Younger
KEYWORDS:
Autoimmune, Encephalitis, Hashimoto, Encephalopathy, Vasculitis
JOURNAL NAME:
World Journal of Neuroscience,
Vol.8 No.1,
February
27,
2018
ABSTRACT: Patients with Hashimoto encephalitis may present
with seizures, stroke-like episodes, transient focal and global neurological
deficits, and a variety of neuropsychiatric disturbances. The encephalopathy
evolves with elevated anti-thyroid peroxidase antibodies, independent of
hormonal thyroid function. A teenager experienced repeated concussions
antedating onset of Hashimoto encephalopathy. Neuroradiological studies showed
overlapping areas of altered brain metabolism and vascular perfusion in the
hippocampus, deemed most vulnerable in autoimmune encephalopathy. Concussive
brain injury may be a contributing factor in the development of
encephalopathy due to its capacity to alter the blood-brain barrier.