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has been cited by the following article:

• TITLE: Ionic Liquid Based Ultrasonic-Assisted Extraction of Oleanolic Acid from Grape Seeds

  AUTHORS: Xifeng Zhang, Xue Li, Qian He, Bin Zhang, Xue Zheng

  KEYWORDS: Ionic-Liquid Based Ultrasound-Assisted (ILUAE), Oleanolic Acid, Grape Seeds

  JOURNAL NAME: Open Access Library Journal, Vol.4 No.12, December 20, 2017

  ABSTRACT: Ionic liquid based ultrasonic-assisted extraction (ILUAE) was successfully applied to extract Oleanolic acid (OA) from grape seeds. Different kinds of 1-alkyl-3-methylimidazolium ionic liquids with different kinds of cations and anions were studied and 1-butyl-3-methylimidazolium chloride ([C4mim]Cl) solution was selected as extractants. The optimal conditions of ILUAE were determined by single factor experiments and Box-Behnken design as follows: [C4mim]Cl concentration of 0.7 mol/L, extraction time of 4 h, liquid-solid ratio of 15:1 mL/g, ultrasonic power of 195 W, the ultrasonication time of 13 min, and extraction temperature of 48℃·min. The extraction yield of OA was 13.4 mg/g, which is well in close agreement with the value predicted by the model. Compared with the regular ultrasonic-assisted extraction (UAE), the proposed approach exhibited 1.64 times higher efficiency, which indicated that ILUAE has a broad prospect for sample preparation of the bioactive compounds.