TITLE:
Protective Effect of Ethanolamine on Hepatic Preneoplastic Alterations Induced by the Administration of N-Nitrosodiethylamine in Rats
AUTHORS:
Hajime Sasaki
KEYWORDS:
Ethanolamine, N-Nitrosodiethylamine, Protection, Hepatic lesion, Cellular Alterations
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.8 No.10,
October
23,
2017
ABSTRACT:
The effects of exogenously administered ethanolamine (Etn) on the N-nitrosodiethylamine
(NDA)-induced formation of hepatic lesions in rats were
investigated. Sprague-Dawley rats were intraperitoneally administered NDA
(100 mg/kg body weight) at 7-day intervals, and the animals were allowed free
access to water containing Etn (15 or 50 mg/L) for 35 days. NDA-induced
hepatic lesions were assessed according to the number of nodules detectable
on the liver surface, areas of clear cell foci observed on histopathological thin
sections, hydroxyproline levels in liver homogenates, and blood biochemical
marker levels. Compared with those from control rats that were not administered
Etn, livers from Etn-exposed rats had significantly fewer surface nodules
and smaller areas of clear cell foci, indicating that Etn prevented or delayed
the formation of preneoplastic cell alterations. Hydroxyproline levels in livers
were significantly lower in Etn-treated rats, indicating that the chemical prevented
the formation of fibrotic alterations. The protective effects of Etn on
NDA-induced hepatic lesions were demonstrated by changes in blood biochemical
marker levels. These results suggest that Etn can protect against cellular
alterations induced by a carcinogenic chemical, possibly by enhancing
hepatic phospholipid synthesis.