Pontikis, K., Karaiskos, I., Bastani, S., Dimopoulos, G., Kalogirou, M., Katsiari, M., Oikonomou, A., Poulakou, G., Roilides, E. and Giamarellou, H. (2014) Outcomes of Critically Ill Intensive Care Unit Patients Treated with Fosfomycin for Infections Due to Pandrug-Resistant and Extensively Drug-Resistant Carbapenemase-Producing Gram-Negative Bacteria. Journal of Antimicrobial Agents, 43, 52-59.

has been cited by the following article:

• TITLE: Effects of Biochemical and Molecular Inhibitors of Plant Extracts on Pathogenic Bacteria

  AUTHORS: Ashwag Al-Zahrani, Effat Al-Judaibi, Hanan Omar, Awatif Al-Judaibi

  KEYWORDS: Natural Products, Antibacterial Activity, Biochemical Analysis, Molecular Analyses, Morphological Changes

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.5 No.5, May 26, 2017

  ABSTRACT: The study aimed to evaluate the effect of the green alga Ulva lactuca and medicinal plant Nigella sativa extract on the activity of Staphylococcus aureus and Pseudomonas aeruginosa. The bacteria were incubated with the crude extracts and extracellular free potassium and phosphorus ions were measured in the medium. The levels of potassium and phosphorous were the maximum in the medium of S. aureus treated with N. sativa extract. The medium of P. aeruginosa incubated with U. lactuca extract was found to have the lowest phosphorous and the greatest potassium levels. The highest activity against P. aeruginosa was noticed with U. lactuca extract, where it caused reduction in the dry weight and glucose consumption of bacteria estimated by 28.41% and 41.09%, respectively. The antibacterial activity of N. sativa extract was the greatest against S. aureus and recorded 32.59% and 39.96% reduction in the bacterial dry weight and glucose uptake, respectively. Scanning Electron Microscopy study showed morphological changes in the cell wall of treated bacteria. The treatment of bacteria with the tested extract induced gene mutations. The results assessed the possible application of U. lactuca and N. sativa as a source of pharmacological benefits.