TITLE:
Eco-friendly Synthesis of Cyclododecanone from Cyclododecatriene
AUTHORS:
Qi Feng, De-Kai Yuan, Dao-Quan Wang, Xiao-Mei Liang, Jian-Jun Zhang, Jin-Ping Wu, Fu-Heng Chen
KEYWORDS:
Eco-Friendly Synthesis, Cyclododecanone, Cyclododecatriene, Hexadecyl Trimethyl Ammonium Heteropolyphosphatotungstate
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.1 No.3,
August
31,
2011
ABSTRACT: An eco-friendly synthesis of cyclododecanone (CDON) from cyclododecatriene (CDT) is described. Selec- tive epoxidation of CDT with hydrogen peroxide using hexadecyl trimethyl ammonium heteropolyphospha- totungstate [(n-C16H33NMe3)3PW4O16, HAHPT] as catalyst and water as solvent followed by the hydrogena- tion on Raney nickel catalyst gave cyclododecanol (CDOL). The latter was oxidized with hydrogen peroxide using HAHPT as catalyst and a mixture of water and t-butanol as solvent to afford CDON. The total yield was 53.4% under the optimum reaction conditions.