Article citationsMore>>
De Angelo, D.J., Stone, R.M., Heany, M.L., Nimer, S.D., Paquette, R.L., Klisovic, R.B., Caligiuri, M.A., Cooper, M.R., Leverf, J., Karol, M.D., Sheng, S., Holford, N., Curtin, P.T., Druker, B.J. and Heinrich, M.C. (2006) Phase 1 Clinical Results with Tandutinib (MLN518), a Novel FLT3 Antagonist, in Patients with Acute Myelogenous Leukemia or High-Risk Myelodysplastic Syndrome: Safety, Pharmacokinetics, and Pharmacodynamics. Blood, 108, 3674-3681.
http://dx.doi.org/10.1182/blood-2006-02-005702
has been cited by the following article:
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TITLE:
Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety
AUTHORS:
Samir B. Salib, Omneya M. Khalil, Mona M. Kamel, Yara El-Dash
KEYWORDS:
Synthesis, Thieno[2, 3-d]Pyrimidine, Thiosemicarbazides, Anticancer Agents
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.7,
July
26,
2016
ABSTRACT:
The present study focused on synthesizing a series of novel derivatives
of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl)
acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The
structure of the synthesized compounds has been elucidated on the basis of
elemental analyses and spectroscopic methods (IR, 1H-NMR, 13C-NMR
and MS). The in vitro cytotoxic activity of the synthesized derivatives
was evaluated against two human cell lines: prostate cancer (PC-3) and colon
cancer (HCT-116).
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