Article citationsMore>>
Moyer, J.D., Barbacci, E.G., Iwata, K.K., Arnold, L., Boman, B., Cunningham, A., Diorio, C., Doty, J., Morin, M.J., Moyer, M.P., Neveu, M., Pollack, V.A., Pustilink, L.R., Reynolds, M.M., Salon, D., Theleman, A. and Miller, P. (1997) Induction of Apoptosis and Cell Cycle Arrest by CP-358,774, an Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinase. Cancer Research, 57, 4838-4848.
has been cited by the following article:
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TITLE:
Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety
AUTHORS:
Samir B. Salib, Omneya M. Khalil, Mona M. Kamel, Yara El-Dash
KEYWORDS:
Synthesis, Thieno[2, 3-d]Pyrimidine, Thiosemicarbazides, Anticancer Agents
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.7,
July
26,
2016
ABSTRACT:
The present study focused on synthesizing a series of novel derivatives
of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl)
acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The
structure of the synthesized compounds has been elucidated on the basis of
elemental analyses and spectroscopic methods (IR, 1H-NMR, 13C-NMR
and MS). The in vitro cytotoxic activity of the synthesized derivatives
was evaluated against two human cell lines: prostate cancer (PC-3) and colon
cancer (HCT-116).
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