TITLE:
Endostatin-Encapsulated N-Succinyl-Chitosan Nanoparticles Inhabited the Growth of MCF-7 Cell
AUTHORS:
Yanrong Fan, Ye Li, Xuefei Xia
KEYWORDS:
N-Succinyl-Chitosan, Nanoparticle, Endostatin
JOURNAL NAME:
Open Access Library Journal,
Vol.2 No.12,
December
10,
2015
ABSTRACT:
A simple method was developed to synthesize the N-succinyl-chitosan (NSC)
successfully. NSC was characterized by FTIR, 1H NMR and element
analysis. The NSC can form nanoparticles with TPP through electrostatic interaction.
The morphology, particle size and zeta potential of the nanoparticle were
investigated and showed a 100 - 200 nm in diameter with a positive potential
9.99 mv. The encapsulation efficiency of
NSC-ES-NPs was 94.76 ± 0.05. The in vitro cell culture indicates that NSC has non-toxicity and cell-compatibility.
NSC-ES-NPs show antitumor activity against MCF-7 cell. Our results demonstrate
that NSC has great potential in the drug controlled release delivery.