TITLE:
Cholangiosepsis Caused by Neutrophilic Cholangitis in Plaque Psoriasis
AUTHORS:
Carina Bergthaler, Ludwig Kramer, Andreas Steiner, Paul Sator
KEYWORDS:
Plaque Psoriasis, Cholangitis, Cholangiosepsis
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.6 No.2,
May
10,
2016
ABSTRACT: Psoriasis
is a common inflammatory skin disease with many comorbid conditions. We present
a 37-year-old male patient with a history of plaque psoriasis, status febrilis,
violent umbilical pain, elevated inflammatory markers and liver parameters.
Blood cultures were tested positive for E. coli. Diagnostic
findings indicated that mechanical icterus and cholangiosepsis in the context
of neutrophilic cholangitis were caused by inflammatory stenosis. Neutrophilic cholangitis
is often found in combination with skin diseases with intense cutaneous
infiltration with polymorphonuclear leucocytes and peripherial blood
neutrophilia. Interleukin-8 may play a role in the pathogenesis of neutrophilic
cholangitis occurring in patients with psoriasis [1]. We
showed that complications of psoriasis can also occur at unusual locations. To
date no case of neutrophilic cholangitis as an elicitor of cholangiosepsis has been reported.