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http://dx.doi.org/10.1007/s10910-007-9340-9

has been cited by the following article:

• TITLE: A Theoretical Model of pH-Based Potentiometric Biosensor Based on Immobilized Enzyme Membrane

  AUTHORS: Jeganathan Saranya, Lakshmanan Rajendran, Mariappan Uma Maheswari

  KEYWORDS: Mathematical Modeling, Reaction-Diffusion, pH-Based Potentiometric Biosensor, Asymptotic Methods, New Homotopy Perturbation Method

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.7 No.4, April 22, 2016

  ABSTRACT: A theoretical model for the non steady-state response of a pH-based potentiometric biosensor immobilizing organophosphorus hydrolase (OPH) is discussed. The model is based on a system of five coupled nonlinear reaction-diffusion equations under non steady-state conditions for enzyme reactions occurring in potentiometric biosensor that describes the concentration of substrate and hydrolysis products within the membrane. New approximate analytical expressions for the concentration of the substrate (organophosphorus pesticides (OPs)) and products are derived for all values of Thiele modulus and buffer concentration using new approach of homotopy perturbation method. The analytical results are also compared with numerical ones and a good agreement is obtained. The obtained results are valid for the whole solution domain.