Huang, S.K., Xiao, H.Q., Kleine-Tebbe, J., Paciotti, G., Marsh, D.G., Lichtenstein, L.M., et al. (1995) IL-13 Expression at the Sites of Allergen Challenge in Patients with Asthma. The Journal of Immunology, 155, 2688-2694.

has been cited by the following article:

• TITLE: Identifying the Roles of Interleukin-13 in Childhood Asthma

  AUTHORS: Kamleshun Ramphul

  KEYWORDS: Asthma, Interleukin 13, Children

  JOURNAL NAME: Open Access Library Journal, Vol.1 No.3, June 18, 2014

  ABSTRACT: Asthma is a chronic inflammatory disease of the airways manifested by reversible airflow obstruction and airway hyperresponsiveness. While recent research has mapped several genes as possible factors predisposing to asthma, interleukin-13 remains one of the most commonly found genes in various populations. IL-13 is a pleiotropic TH2 cytokine which has been linked to cause an increase in goblet cell differentiation, activation of fibroblasts, elevation of bronchial hyperresponsiveness and switching of B cell antibody from IgM to IgE. The aim of this review is to study and identify the three main single-nucleotide polymorphisms of IL-13 (IL13 R130Q, IL-13Rα1 and IL-13 A2044G) that have been linked to asthma in children, and to understand their respective roles in the pathogenesis of this disease.