TITLE:
HLA allele frequencies in Iranian opticospinal multiple sclerosis patients——HLA in Opticospinal MS
AUTHORS:
Hossein Kalanie, Malihe Kamgooyan, Yadollah Kholghie, Ali Amini Harandi, Zahra Hosseinzadeh
KEYWORDS:
Epidemiology, HLA-Class II Allele
Frequency, Opticospinal Multiple Sclerosis;
Neuromyelitis Optica; NMO-Igg Antibody; Devic’s Neuromyelitis Optica; Iranian; Demyelinating Disease
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.4 No.7,
July
28,
2011
ABSTRACT: Background: In Iranian patients with opticospinal multiple sclerosis (OSMS), a paucity of brain lesions and short spinal cord lesions extending less than three spinal segments are characteristic findings on magnetic resonance imaging (MRI). It also shows a relatively benign course with negative CSF oligo-coonal bands. Objective: We aimed to clarify the possible relationship between clinical phenotype and MRI features of OSMS and human leucocyte antigen (HLA) system in Iran. Methods: Genotyping of HLA class II allele frequencies in 20 patients with OSMS were done, using polymerase chain reaction sequence-specific primer amplification method. Blood samples were extracted and typed for HLA-DRB, DQA, and DQB loci and compared with 100 controls. Results: Significant positive association was observed in DRB1*03, DQA1*0201, DQA1*03, DQB1*0201, and DQB1*0611, while DQB1*0602 was absent in our patients. Conclusion: These finding suggest that HLA-DRB association pattern in OSMS is different from conventional MS in Iran which is mostly associated with DRB1*1501 and from similar Japanese OSMS who are negative for brain lesions fulfilling the Barkhof criteria and negative for the presence of longitudinally extensive spinal cord lesions who carries the DRB*0405 allele. OSMS is immunogenetically heterogeneous. Also absence of DQB1*0602 allele may negatively be associated with the absence of Barkhof brain lesion.